TIL（肿瘤浸润淋巴细胞）与肿瘤相关巨噬细胞作为大唾液腺癌淋巴结转移的潜在预测因子

英文原题：Tumor-infiltrating lymphocytes and tumor-associated macrophages as potential predictors of lymph node metastases in major salivary gland cancers.

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Tumor-infiltrating lymphocytes and tumor-associated macrophages as potential predictors of lymph node metastases in major salivary gland cancers.

PubMed 2023/07/03（内容时间） Front Med (Lausanne) Q1 · IF 3.6（JCR 2025）

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研究概要

特定 TIL 和 TAM 亚群的高密度可能与 SGC 中 LNM 的较高概率相关。

研究思路结论见上方概要

目的

本研究的目的是明确TIL（肿瘤浸润淋巴细胞）（TILs）和肿瘤相关巨噬细胞（TAMs）是否可作为唾液腺癌（SGC）淋巴结转移（LNM）的潜在预测因子。

方法

选取了一组与 TIL（CD3、CD4、CD68 和 FOXP3）及 TAM（CD68 和 CD163）相关的免疫组化标志物，在主要唾液腺癌中进行研究。使用开源软件 QuPath 在数字图像上分别测量肿瘤内部（TI）和浸润边缘（IM）的 TIL 和 TAM 密度。研究了其与病理 N 分期及随访临床数据的相关性。

结果

共纳入25例连续患者（男性：11例；中位年龄：62.0岁）。CD3+ IM（OR = 7.7，95% CI 1.2-51.2）、CD8+ TI（OR = 7.7，95% CI 1.2-51.2）、CD8+ IM（OR = 7.7，95% CI 1.2-51.2）、FOXP3+ TI（OR = 24.0，95% CI 2.2-255.9）、CD68+ TI（OR = 7.7，95% CI 1.2-51.2）和CD163+ IM（OR = 7.7，95% CI 1.2-51.2）的密度，以及Immunoscore CD8/CD3（OR = 1.9，95% CI 1.1-3.4）与LNM显著相关（p < 0.05）。CD3+ TI密度与肿瘤复发和死亡显著相关（HR = 5.8，95% CI 1.5-22.6；p < 0.05）。

展开英文摘要原文

PURPOSE

The purpose of this study is to define if tumor-infiltrating lymphocytes (TILs) and tumor-associated macrophages (TAMs) could represent potential predictors of lymph node metastases (LNM) in salivary gland cancers (SGC).

METHODS

A selected number of immunohistochemical markers related to TILs (CD3, CD4, CD68, and FOXP3) and TAMs (CD68 and CD163) were investigated on major salivary gland cancers. TIL and TAM densities were measured on digital images using the open-source QuPath both in the tumor interior (TI) and invasive margin (IM). Correlation with pathologic N classification and follow-up clinical data was investigated.

RESULTS

A total of 25 consecutive patients (men: 11; median age: 62.0) were included. Densities of CD3+ IM (OR = 7.7, 95% CI 1.2-51.2), CD8+ TI (OR = 7.7, 95% CI 1.2-51.2), CD8+ IM (OR = 7.7, 95% CI 1.2-51.2), FOXP3+ TI (OR = 24.0, 95% CI 2.2-255.9), CD68+ TI (OR = 7.7, 95% CI 1.2-51.2), and CD163+ IM (OR = 7.7, 95% CI 1.2 - 51.2), and the Immunoscore CD8/CD3 (OR = 1.9, 95% CI 1.1-3.4) were significantly associated with LNM ( p < 0.05). CD3+ TI density was significantly associated with tumor recurrence and death (HR = 5.8, 95% CI 1.5-22.6; p < 0.05).

CONCLUSION

A high density of specific TIL and TAM subpopulations might be correlated with a higher probability of LNM in SGC.

论文信息

作者: De Virgilio A、Veneroni MV、Costantino A、Festa BM、Fiamengo B、Sebastiani D、Spriano G、Di Tommaso L
单位: Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, MI, Italy.Italy
期刊: Frontiers in medicine2023

原文标识: PubMed 37465638　·　DOI 10.3389/fmed.2023.1163565

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