为肝细胞癌武装 GPC3 CAR-T 细胞：多少才足够，下一步是什么？
Armouring GPC3 CAR T cells for hepatocellular carcinoma: how much is enough and what comes next?
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
肿瘤微环境中浸润免疫细胞对肝细胞癌转移的影响
英文原题：Effect of infiltrating immune cells in tumor microenvironment on metastasis of hepatocellular carcinoma.
查看英文原题
Effect of infiltrating immune cells in tumor microenvironment on metastasis of hepatocellular carcinoma.
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中文摘要
肝细胞癌（HCC）是最致命和最常见的人类恶性肿瘤之一，由于其高复发率和转移率，导致预后不良。近年来，越来越明显的是，肿瘤微环境（TME）在肿瘤进展和转移中起着重要作用。肿瘤微环境（TME）是指肿瘤发生和发展的复杂组织环境。在此，我们总结了HCC的发展以及TME的细胞和非细胞成分在HCC转移中的作用，特别提到了肿瘤浸润免疫细胞。我们还讨论了TME的一些可能的治疗靶点以及这一不断发展的领域的未来前景。意义：这篇综述全面分析了TME中浸润免疫细胞在HCC转移中的作用，并结合最近揭示的针对TME的若干治疗靶点的实验，强调了TME靶向治疗的未来展望。
展开英文摘要原文
Hepatocellular carcinoma (HCC) is one of the most lethal and prevalent human malignancies, leading to poor prognosis due to its high recurrence and metastasis rates. In recent years it has become increasingly evident that the tumor microenvironment (TME) plays an important role in tumor progression and metastasis. Tumor microenvironment (TME) refers to the complex tissue environment of tumor occurrence and development.
Here, we summarize the development of HCC and the role of cellular and non-cellular components of the TME in the metastasis HCC, with particular reference to tumor-infiltrating immune cells.
We also discuss some of the possible therapeutic targets for the TME and the future prospectives of this evolving field. SIGNIFICANCE: This review provides a comprehensive analysis of the role of the infiltrating immune cells in TME in the metastasis of HCC and highlights the future outlook for targeted therapy of the TME in the context of recent experiments revealing a number of therapeutic targets targeting the TME.
论文信息
- 作者
- Chen Y、Zhou Y、Yan Z、Tong P、Xia Q、He K
- 第一作者单位
- Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.China
- 通讯作者单位
- Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. hekang929@163.com.China
- 文献类型
- 综述
- 期刊
- Cellular oncology (Dordrecht, Netherlands)2023 Dec
- 原文标识
- PubMed 37414962 · DOI 10.1007/s13402-023-00841-6
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