工程化益生菌用于肿瘤靶向联合化学免疫治疗
Engineered probiotics for tumor-targeted combination chemoimmunotherapy.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
靶向多种癌症抗原的 T 细胞疗法：众志成城
英文原题：T-cell Therapies Targeting Multiple Cancer Antigens: The Power of Many.
查看英文原题
T-cell Therapies Targeting Multiple Cancer Antigens: The Power of Many.
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中文摘要
在本期中，Tsimberidou及其同事报告了一项首次人体临床试验的结果，该试验在转移性实体瘤患者中使用个体化、多靶点、内源性T细胞疗法。这一结果以及其他近期发表的临床试验结果，证实了多靶点方法的合理性，该方法可以增加肿瘤反应并对抗肿瘤异质性和免疫逃逸机制。参见Tsimberidou等人的相关文章，第925页（4）。
展开英文摘要原文
In this issue, Tsimberidou and colleagues report the results of a first-in-human clinical trial using a personalized, multi-target, endogenous T-cell therapy in patients with metastatic solid tumors. This, and results of other recently published clinical trials, confirms the rationale of multi-target approaches that can increase tumor responses and counteract tumor heterogeneity and mechanisms of immune evasion. See related article by Tsimberidou et al., p. 925 (4).
论文信息
- 作者
- Uslu U、June CH
- 单位
- Center for Cellular Immunotherapies and Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.United States
- 文献类型
- 社论 · 美国 NIH 资助研究 · 非美国政府资助研究 · 评论
- 期刊
- Cancer immunology research2023 Jul 5
- 原文标识
- PubMed 37347991 · DOI 10.1158/2326-6066.CIR-23-0160