CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
CAR-T 细胞治疗：设计、注射、浸润与作用环节当前挑战的解决策略
英文原题：CAR T Cell Therapy: Remedies of Current Challenges in Design, Injection, Infiltration and Working.
查看英文原题
CAR T Cell Therapy: Remedies of Current Challenges in Design, Injection, Infiltration and Working.
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中文摘要
嵌合抗原受体（CAR）T细胞疗法作为一种创新的免疫疗法，在当前癌症治疗中发挥着巨大作用。尽管CAR-T 细胞疗法已在某些B细胞白血病或淋巴瘤亚型中显示出治疗效果，但仍有许多挑战限制了CAR-T 细胞在实体瘤中的治疗疗效。如何高效地将CAR-T 细胞运输至肿瘤组织是我们持续关注的问题。在本综述中，我们对实验进行了广泛研究和比较。我们最终比较了不同注射方式对治疗疗效的影响。我们还仔细探讨了CAR-T 细胞在设计、归巢和工作方面的困难，并最终为每个过程提出了更好的解决方案，以帮助CAR-T 细胞更高效、更快速地到达肿瘤组织。这些结果将对指导CAR-T 细胞疗法在癌症治疗中的应用具有重要意义。
展开英文摘要原文
Chimeric antigen receptor (CAR) T cell therapy, as an innovative immunotherapy, plays a huge role in current cancer therapy. Although CAR T cell therapy has demonstrated therapeutic effects in some subtypes of B cell leukemia or lymphoma, there are many challenges that limit the therapeutic efficacy of CAR T cells in solid tumors. And how to efficiently transport CAR T cells to tumor tissues is a continuing concern for us. In this review, experiments have been extensively studied and compared.
We finally compared the influence of different injection methods on therapeutic efficacy.
We also carefully explored the difficulties of designing, homing, and working of CAR T cells, and ultimately came up with better solutions for each process to help CAR T cells reach tumor tissue more efficiently and quickly. These results will have significant implications for guiding CAR T cell therapy in cancer treatment.
论文信息
- 作者
- Zhu Y、Feng J、Wan R、Huang W
- 第一作者单位
- The First Clinical Medical School, Southern Medical University, Guangzhou, People's Republic of China.China
- 通讯作者单位
- Guangdong Provincial Key Laboratory of Digital Medicine and Biomechanics, National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, People's Republic of China.China
- 文献类型
- 综述
- 期刊
- Drug design, development and therapy2023
- 原文标识
- PubMed 37337518 · DOI 10.2147/DDDT.S413348
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