CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题:Therapeutic Approaches to Penile Cancer: Standards of Care and Recent Developments.
Therapeutic Approaches to Penile Cancer: Standards of Care and Recent Developments.
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阴茎癌是一种罕见的恶性肿瘤,最常见于老年男性,与不良预后、生活质量和性功能的显著下降相关。鳞状细胞癌是阴茎癌最常见的组织病理学类型,占所有病例的95%。局限性、早期阴茎癌在许多情况下可通过保留阴茎的技术得到有效治疗,尽管晚期阴茎癌预后较差。当前的创新治疗正在探索靶向治疗、HPV导向治疗、免疫检查点抑制剂和过继性T细胞疗法在阴茎癌治疗和预防复发中的作用。临床试验正在研究靶向治疗和免疫检查点抑制剂在晚期阴茎癌中的潜力。本综述探讨了阴茎癌的当前管理,并强调了研究和治疗的未来方向。
Penile cancer is a rare malignancy, most commonly diagnosed in older men, associated with poor outcomes, dramatic decline in quality of life and sexual function. Squamous cell carcinoma is the most common histopathology of penile cancer, accounting for 95% of all cases. Localized, early-stage penile cancer can be effectively managed through penile-sparing techniques in many cases, though advanced stages of penile cancer carry a poor prognosis.
Current innovative treatments are exploring the role of targeted therapy, HPV-directed therapy, immune checkpoint inhibitors and adoptive T-cell therapies in treatment and prevention of relapse of penile cancer. Clinical trials are investigating the potential of targeted therapies and immune checkpoint inhibitors in advanced penile cancer. This review examines the current management of penile cancer and highlights future directions in research and treatment.
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