CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
病例报告：弥漫大 B 细胞淋巴瘤 CAR-T 细胞治疗后出现 IBD 样结肠炎
英文原题：Case Report: IBD-like colitis following CAR T cell therapy for diffuse large B cell lymphoma.
查看英文原题
Case Report: IBD-like colitis following CAR T cell therapy for diffuse large B cell lymphoma.
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中文摘要
嵌合抗原受体（CAR）T细胞疗法已成为几种血液系统恶性肿瘤治疗的新支柱，但相关并发症的谱系仍未完全明确。在此，我们报告一例70岁女性患者，因弥漫性大B细胞淋巴瘤（DLBCL）接受tisagenlecleucel治疗，随后出现具有炎症性肠病（IBD）样结肠炎特征的慢性腹泻。CAR-T 细胞在结肠固有层中显著富集，其他诊断均被排除。因此，我们得出结论，该患者的IBD样结肠炎与CAR-T 细胞疗法相关，需将其视为一种罕见的潜在并发症。
展开英文摘要原文
Chimeric antigen receptor (CAR) T cell therapy has become a new mainstay in the treatment of several hematologic malignancies, but the spectrum of associated complications is still incompletely defined.
Here, we report the case of a 70-year-old female patient treated with tisagenlecleucel for diffuse large B cell lymphoma (DLBCL), who developed chronic diarrhea with characteristics of inflammatory bowel disease (IBD)-like colitis. CAR T cells were substantially enriched in the colon lamina propria and other diagnoses were ruled out.
Thus, we conclude that IBD-like colitis in this patient was associated to CAR T cell therapy and needs to be considered as a rare potential complication.
论文信息
- 作者
- Zundler S、Vitali F、Kharboutli S、Völkl S、Polifka I、Mackensen A、Atreya R、Neurath MF
- 第一作者单位
- Department of Medicine 1 - Gastroenterology, Pneumology, Endocrinology, University Hospital Erlangen, Erlangen, Germany.Germany
- 通讯作者单位
- University Hospital Erlangen, Deutsches Zentrum Immuntherapie, Erlangen, Germany.Germany
- 文献类型
- 病例报告
- 期刊
- Frontiers in oncology2023
- 原文标识
- PubMed 37284193 · DOI 10.3389/fonc.2023.1149450
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