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合并心肌病或心脏淋巴瘤浸润的淋巴瘤患者的 CAR-T 治疗

英文原题:CAR-T Therapy in Lymphoma Patients With Coexisting Cardiomyopathy or Cardiac Lymphomatous Involvement.

查看英文原题

CAR-T Therapy in Lymphoma Patients With Coexisting Cardiomyopathy or Cardiac Lymphomatous Involvement.

PubMed 2023/04/21(内容时间) JACC Case Rep

分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。

中文摘要

CAR-T 细胞疗法已经彻底改变了侵袭性血液系统恶性肿瘤的治疗。然而,由于可能出现室壁破裂、心脏压塞和循环衰竭等潜在危及生命的并发症,其在淋巴瘤合并心脏转移或心肌病患者中的作用仍不明确。我们呈现了一组接受CAR-T 细胞治疗的淋巴瘤合并心肌病或心脏转移患者的病例系列。(难度等级:高级。)

展开英文摘要原文

Chimeric antigen receptor T-cell (CAR-T) therapy has revolutionized the management of aggressive hematologic malignancies.

However, its role in patients with lymphoma and cardiac metastasis or cardiomyopathy remains undefined due to potentially life-threatening complications such as ventricular rupture, cardiac tamponade, and circulatory failure.

We present a case series of patients with lymphoma and cardiomyopathy or cardiac metastasis managed with chimeric antigen receptor T-cell therapy. ( Level of Difficulty: Advanced. ).

论文信息

作者
Ng CT、Gonzalez Bonilla HM、Chang I、Aung MT、Gile JJ、Pereira NL、Villasboas Bisneto JC、Johnston PB
单位
Department of Cardiovascular Medicine, Mayo Clinic Rochester, Rochester, Minnesota, USA.United States
文献类型
病例报告
期刊
JACC. Case reports2023 Jun 7
原文标识
PubMed 37283829 · DOI 10.1016/j.jaccas.2023.101840