CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
环状 RNA 在肿瘤免疫与免疫治疗中的作用：来自固有免疫与适应性免疫的视角
英文原题：CircRNAs in tumor immunity and immunotherapy: Perspectives from innate and adaptive immunity.
查看英文原题
CircRNAs in tumor immunity and immunotherapy: Perspectives from innate and adaptive immunity.
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中文摘要
肿瘤免疫治疗是近十年来不断发展的一种新的治疗方法，极大地改变了癌症的治疗选择。环状RNA（circRNA）是一类具有高稳定性、组织特异性和细胞特异性表达的非编码RNA（ncRNA）。越来越多的证据表明，circRNA参与适应性免疫和固有免疫的调节。它们通过影响巨噬细胞、NK细胞和T细胞功能，在肿瘤免疫治疗中发挥重要作用。高稳定性和组织特异性使其成为理想的治疗效果候选生物标志物。circRNA也是免疫治疗的有前景的靶点或佐剂之一。该领域的研究进展迅速，为未来癌症的诊断、预后和治疗指导提供了重要支持。在这篇综述中，我们从固有免疫和适应性免疫的角度总结了circRNA对肿瘤免疫的作用，并探讨了circRNA在肿瘤免疫治疗中的作用。
展开英文摘要原文
Tumor immunotherapy is a new therapeutic approach that has been evolving in the last decade and has dramatically changed the treatment options for cancer. Circular RNAs (circRNAs) are non-coding RNAs (ncRNAs) with high stability, tissue-specific and cell-specific expression. There is growing evidence that circRNAs are involved in the regulation of both adaptive and innate immunity. They play important roles in tumor immunotherapy by affecting macrophage, NK and T cell function.
The high stability and tissue specificity make them ideal candidate biomarkers for therapeutic effects. CircRNAs also represent one of promising targets or adjuvant for immunotherapy. Investigations in this field progress rapidly and provide essential support for the diagnosis, prognosis and treatment guidance of cancers in the future. In this review, we summarize the role of circRNAs on tumor immunity from the viewpoint of innate and adaptive immunity, and explore the role of circRNAs in tumor immunotherapy.
论文信息
- 作者
- Yu LL、Xiao Q、Yu B、Lv QL、Liu ZQ、Yin JY
- 第一作者单位
- Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410078, PR China; Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha, 410078, PR China; Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, 110 Xiangya Road, Changsha, 410078, PR China; National Clinical Research Center for Geriatric Disorders, 87 Xiangya Road, Changsha, 410008, Hunan, PR China.China
- 通讯作者单位
- Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410078, PR China; Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha, 410078, PR China; Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, 110 Xiangya Road, Changsha, 410078, PR China; National Clinical Research Center for Geriatric Disorders, 87 Xiangya Road, Changsha, 410008, Hunan, PR China. Electronic address: yinjiye@csu.edu.cn.China
- 文献类型
- 综述 · 非美国政府资助研究
- 期刊
- Cancer letters2023 Jun 28
- 原文标识
- PubMed 37146937 · DOI 10.1016/j.canlet.2023.216219