CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题：T-Cell Receptor Repertoire Characteristics Associated with Prognostic Significance in High-Grade Serous Ovarian Carcinoma.
T-Cell Receptor Repertoire Characteristics Associated with Prognostic Significance in High-Grade Serous Ovarian Carcinoma.
分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。
高级别浆液性卵巢癌（HGSOC）是一种致死性妇科恶性肿瘤。T细胞受体（TCR）发育过程中发生的体细胞重组形成TCR多样性，进而产生的TCR库与免疫应答相关。本研究分析51例HGSOC患者TCR库的差异及其预后意义。研究评估患者临床特征、基因表达模式、TCR克隆型和肿瘤浸润白细胞（TIL）程度，并依据复发模式、TIL评分及同源重组修复通路缺陷（HRD）相关突变对患者分组。复发患者的TCR库多样性较低，并出现8个TCR片段扩增。值得注意的是，若干与TCR相关的基因也呈现与预后相关的表达差异，其中7个基因参与免疫应答，KIAA1199在卵巢癌中表达上调。本研究表明，卵巢癌患者TCR库及相关免疫通路的差异可能影响HGSOC预后。
High-grade serous ovarian carcinoma (HGSOC) is a fatal gynecological malignancy. Somatic recombination occurring during T-cell receptor (TCR) development results in TCR diversity, and the TCR repertoire, thus produced, is associated with immune response.
This study analyzed the difference in the TCR repertoire and their prognostic significance in 51 patients with HGSOC. The patient's clinical characteristics, gene expression pattern, TCR clonotypes, and degree of tumor-infiltrating leukocytes (TILs) were analyzed, and the patients were divided into groups depending on their recurrence pattern, tumor-infiltrating leukocyte (TIL) score, and homologous recombinant repair pathway deficiency (HRD)-associated mutations.
The TCR repertoire was low in patients with recurrence and showed the expansion of eight TCR segments. Interestingly, a few genes correlated with the TCRs also showed a difference in expression according to the prognosis. Among them, seven genes were related to immune responses and KIAA1199 was up-regulated in ovarian cancer.
Our study shows that the differences in the TCR repertoire in patients with ovarian cancer and their associated immune pathways could affect the prognosis of HGSOC.
在 PubMed 查看 → 出版商原文（DOI） 全文 PDF（PMC）· 可下载 治疗专题与资料阅读指南 资料来源与翻译说明 报告译文或资料问题 →
MEMBER ACCOUNT
登录成功会直接打开下一页。
