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肿瘤免疫治疗的最新进展与未来前景

英文原题:Current Advances and Future Prospects in Cancer Immunotherapeutics.

查看英文原题

Current Advances and Future Prospects in Cancer Immunotherapeutics.

PubMed 2023/03/28(内容时间) Medeni Med J Q2 · IF 1.5(JCR 2025)

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中文摘要

癌症是一种细胞不受控制地增殖和生长所致疾病。得益于早期检测方法,许多癌症的死亡率有所下降。然而,在全球死因中,癌症仍仅次于心血管疾病,位居第二。因此,癌症研究主要致力于开发更有效的治疗方法以减少癌症死亡。随着人们更好地理解癌细胞分子机制,癌症治疗不断发展和改变。研究首要任务是开发缓解率最高、副作用最少的治疗方式。在此背景下,免疫疗法开启了癌症治疗新时代。本文介绍最常用的免疫疗法,并概述下一代治疗方法的发展前景。

展开英文摘要原文

Cancer is a disease that results from the uncontrolled proliferation and growth of cells. Due to early detection methods, there is a decrease in death rates in many types of cancer.

However, among the causes of death worldwide, cancer still ranks second after cardiovascular diseases.

Therefore, cancer research has focused mainly on developing more effective treatments to reduce deaths from cancer. With a better understanding of the molecular mechanisms in cancer cells, advances in cancer treatment have evolved and changed. The main priority of research is to develop treatment modalities with the highest response rate and less side effects. In this context, immunotherapies have started a new era in cancer treatments. In this review, an overview of the future of next-generation treatment methods is presented by including the most preferred immunotherapy methods. Kanser, h crelerin kontrols z ekilde o almas ve b y mesi sonucu olu an bir hastal kt r. Erken te his y ntemleri sayesinde bir ok kanser t r nde l m oranlar nda d ya anmaktad r.

Ancak t m d nyada l m nedenleri aras nda kanser, kardiyovask ler hastal klardan sonra halen ikinci s radad r. Bu nedenle, kanser ara t rmalar n n o u kanserden l mleri azaltmak i in daha etkin tedaviler geli tirmeye odaklanm t r. Kanser h cresindeki molek ler mekanizmalar n daha da iyi anla lmas yla kanser tedavisindeki geli meler, zaman i inde geli mi ve de i mi tir.

Ara t rmalar n temel nceli i en y ksek yan t oran na ve en d k yan etkiye sahip tedavi y ntemleri geli tirmektir. mm noterapiler bu ba lamda kanser tedavilerinde yeni bir d nemi ba latm t r. Bu derlemede en ok tercih edilen imm noterapi y ntemlerine yer verilerek yeni nesil tedavi y ntemlerinin gelece ine dair genel bir bak a s sunulmu tur.

论文信息

作者
Dede Z、Tumer K、Kan T、Yucel B
第一作者单位
Health Institutes of Turkey, Turkey Biotechnology Institute, Istanbul, Turkey.Turkey
通讯作者单位
Health Institutes of Turkey, Turkey Cancer Institute; Istanbul Medeniyet University Faculty of Medicine, Department of Medical Biology, Istanbul, Turkey.Turkey
期刊
Medeniyet medical journal2023 Mar 28
原文标识
PubMed 36974661 · DOI 10.4274/MMJ.galenos.2023.29599