CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
撞击与逃逸：CAR-T 治疗后双侧眼内大面积淋巴瘤浸润
英文原题：Hit and Run: Bilateral Massive Intraocular Lymphomatous Infiltration after CAR-T Therapy.
查看英文原题
Hit and Run: Bilateral Massive Intraocular Lymphomatous Infiltration after CAR-T Therapy.
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研究概要
弥漫大 B 细胞淋巴瘤的非典型眼内转移可能发生在 CAR-T 治疗之后，并可能提示眼等免疫豁免部位内免疫监视的继发性改变。
中文摘要
目的
报告一例 CAR-T 治疗后发生双眼眼内弥漫大 B 细胞淋巴瘤（DLBCL）浸润的病例。
方法
回顾性病例报告。
结果
一名 62 岁白人男性，既往患高级别 DLBCL，在完成 CAR-T 治疗后出现视乳头炎和玻璃体炎。研究者进行了全面感染和诊断检查。诊断性玻璃体穿刺显示眼内淋巴瘤。患者接受双侧眼眶外照射放疗，视盘水肿和玻璃体炎显著改善。然而，后续 MRI 显示颅内转移性疾病，患者在同月内死亡。
结论
DLBCL 治疗后可能发生非典型眼内转移，或提示眼等免疫豁免部位的免疫监视发生继发性改变。
展开英文摘要原文
PURPOSE
We report a case of bilateral intraocular infiltration of DLBCL after CAR-T therapy.
METHODS
Retrospective case report.
RESULTS
A 62-year-old Caucasian male with medical history of high-grade DLBCL presented with papillitis and vitritis upon completion of CAR-T therapy. Thorough infectious and diagnostic work-ups were performed. Diagnostic vitreous tap revealed intraocular lymphoma. The patient received external beam radiotherapy to both orbits with dramatic improvement in disc edema and vitritis. However, subsequent MRI showed development of intracranial metastatic disease, and the patient died within the same month.
CONCLUSION
Atypical intraocular metastasis of DLBCL may occur following CAR-T therapy and may indicate secondary changes in immunosurveillance within immune-privileged sites such as the eye.
论文信息
- 作者
- Abou-Samra A、McTavish S、Whitehair R、Shildkrot YE
- 单位
- Department of Ophthalmology, University of Virginia, Charlottesville, Virginia, USA.United States
- 文献类型
- 病例报告 · 读者来信
- 期刊
- Ocular immunology and inflammation2024 Sep
- 原文标识
- PubMed 36952531 · DOI 10.1080/09273948.2023.2191713