不适合移植的大 B 细胞淋巴瘤二线使用 axicabtagene ciloleucel：ALYCANTE 最终分析
Second-line axicabtagene ciloleucel in large B-cell lymphoma ineligible for transplantation: ALYCANTE final analysis.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
西方人群中的结外鼻型 NK/T 细胞淋巴瘤：分子谱分析确定新的治疗靶点
英文原题：Extranodal natural killer/T-cell lymphoma nasal type in a western population: Molecular profiling identifies new therapeutic targets.
查看英文原题
Extranodal natural killer/T-cell lymphoma nasal type in a western population: Molecular profiling identifies new therapeutic targets.
分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。
中文摘要
(A) 基于NanoString平台包含的208个基因的无监督共调控基因相关矩阵。一些共调控基因簇对应以下类别：炎症细胞；Epstein-Barr病毒；B细胞；细胞毒性T细胞；T细胞；以及增殖。(B) 通过靶向测序分析基因组改变。62个分析基因中突变的分布。行对应测序基因，列代表个别患者。颜色编码：绿色，错义；蓝色，同义；粉色，移码；紫色，Indel；红色，终止获得；黄色，UTR。
展开英文摘要原文
(A) Correlation matrix of unsupervised co-regulated genes, based on the 208 genes included in the NanoString platform. Some of the clusters of co-regulated genes corresponded to the following: Inflammatory cells; Epstein-Barr virus; B-cells; Cytotoxic T-cells; T-cells; and Proliferation.
(B) Analysis of genomic alterations by targeted sequencing. Distribution of mutations in the 62 analyzed genes. Rows correspond to sequenced genes, columns represent individual patients. Color coding: green, missense; blue, synonymous; pink, frameshift; violet, Indel; red, stop gained; yellow, UTR.
论文信息
- 作者
- Gonzalez Barca E、Tomás-Roca L、Esteve A、Rodriguez M、Gato L、Alonso-Alonso R、Martin Garcia-Sancho A、Cordoba R
- 第一作者单位
- Hematology Department, Institut Català d'Oncologia Hospitalet, Hospital Duran i Reynals, IDIBELL, Universitat de Barcelona, Barcelona, Spain.Spain
- 通讯作者单位
- Pathology Department, Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Madrid, Spain.Spain
- 文献类型
- 读者来信 · 非美国政府资助研究
- 期刊
- American journal of hematology2023 Jun
- 原文标识
- PubMed 36882876 · DOI 10.1002/ajh.26904