CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
接受 CAR-T 细胞治疗的侵袭性淋巴瘤和急性淋巴细胞白血病成人患者中的神经精神障碍
英文原题：Neuropsychiatric disorders in adults undergoing chimeric antigen receptor T cells therapy for aggressive lymphomas and acute lymphoblastic leukemia.
查看英文原题
Neuropsychiatric disorders in adults undergoing chimeric antigen receptor T cells therapy for aggressive lymphomas and acute lymphoblastic leukemia.
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研究概要
31.2% 的患者被诊断为 NPD。与无 NPD 的患者相比，NPD 患者更可能为女性（P = 0.035）并患有 ALL（P = 0.039）。NPD 与女性性别（OR = 2.03）和 ALL 诊断（OR = 2.76）显著相关。NPD 与结局之间无关联。
研究思路结论见上方概要
目的
评估接受 CAR-T 治疗者中神经精神障碍（NPD）的风险因素。
方法
对2018年接受CAR-T 治疗的年龄≥18岁的急性淋巴细胞白血病（ALL）和侵袭性B细胞淋巴瘤患者进行了评估。比较了有无NPD的患者。
结果
31.2%的患者被诊断为NPD。与无NPD的患者相比，NPD患者更可能为女性（P = 0.035）并患有ALL（P = 0.039）。NPD与女性性别（OR = 2.03）和ALL诊断（OR = 2.76）显著相关。NPD与结局之间无关联。
展开英文摘要原文
OBJECTIVE
To evaluate risk factors for neuropsychiatric disorders (NPD) in recipients of CART therapy.
METHODS
Patients ≥ 18 years with acute lymphoblastic leukemia (ALL), and aggressive B-cell lymphomas who received CART in 2018 were evaluated. Patients with and without NPD were compared.
RESULTS
NPD was diagnosed in 31.2% of patients. Compared to patients without NPD, patients with NPD were likely to be females ( P = 0.035) and have ALL ( P = 0.039). NPD was significantly associated with female gender (OR = 2.03) and diagnosis of ALL (OR = 2.76). No association between NPD and outcomes.
CONCLUSIONS
Female gender and ALL were risk factors for NPD.
论文信息
- 作者
- Emole J、Lawal O、Lupak O、Rangarajan H、Udo I
- 第一作者单位
- Stem Cell Transplantation and Cellular Therapy, Henry Ford Hospital, Detroit, MI, United States.United States
- 通讯作者单位
- Department of Psychiatry, Western University, London, Ontario, Canada.Canada
- 期刊
- Leukemia research reports2023
- 原文标识
- PubMed 36873581 · DOI 10.1016/j.lrr.2023.100364
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