CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题：Cytomegalovirus seropositivity is associated with improved responses to CD38 monoclonal antibody therapies in multiple myeloma: A single-centre retrospective study.
Cytomegalovirus seropositivity is associated with improved responses to CD38 monoclonal antibody therapies in multiple myeloma: A single-centre retrospective study.
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靶向CD38的单克隆抗体（CD38 mAb）是治疗多发性骨髓瘤（MM）的成熟疗法，但治疗反应并不总是深入或持久。缺乏Fc epsilon受体γ亚基的自然杀伤（NK）细胞，即g-NK细胞，在暴露于巨细胞病毒（CMV）的个体中数量较多，并且能够在体内增强daratumumab的疗效。
在此，我们呈现了一项单中心、回顾性分析，纳入136例已知CMV血清状态的MM患者，这些患者接受了含CD38 mAb的方案（93.4%为daratumumab，6.6%为isatuximab）。CMV血清阳性与含CD38 mAb治疗方案的总缓解率升高相关（比值比2.65，95%置信区间[CI] 1.17-6.02）。
然而，在多变量Cox模型中，CMV血清状态与更短的治疗失败时间相关（CMV血清阳性组与CMV血清阴性组分别为7.8个月 vs. 8.8个月，log-rank p = 0.18，风险比1.98，95% CI 1.25-3.12）。
我们的数据提示，CMV血清阳性可能预测对CD38 mAb更好的反应，尽管这并未对应更长的治疗失败时间。需要更大规模、直接定量g-NK细胞的研究，以充分理解其对MM中CD38 mAb疗效的影响。
The CD38-targeting monoclonal antibodies (CD38 mAbs) are well-established therapies in multiple myeloma (MM), but responses to treatment are not always deep or durable. Natural killer (NK) cells deficient in Fc epsilon receptor gamma subunits, known as g-NK cells, are found in higher numbers among individuals exposed to cytomegalovirus (CMV) and are able to potentiate the efficacy of daratumumab in vivo.
Here, we present a single-centre, retrospective analysis of 136 patients with MM with known CMV serostatus who received a regimen containing a CD38 mAb (93. 4% daratumumab and 6. 6% isatuximab). CMV seropositivity was associated with an increased overall response rate to treatment regimens containing a CD38 mAb (odds ratio 2. 65, 95% confidence interval [CI] 1. 17-6. 02).
However, CMV serostatus was associated with shorter time to treatment failure in a multivariate Cox model (7. 8 vs. 8. 8 months in the CMV-seropositive vs. CMV-seronegative groups respectively, log-rank p = 0. 18, hazard ratio 1. 98, 95% CI 1. 25-3. 12).
Our data suggest that CMV seropositivity may predict better response to CD38 mAbs, although this did not correspond to longer time to treatment failure. Larger studies directly quantitating g-NK cells are required to fully understand their effect on CD38 mAb efficacy in MM.
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