CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
CD8⁺ T 细胞与 PD-L1 表达作为低发病率 HPV 相关口咽鳞状细胞癌的预后指标
英文原题：CD8+ T Cells and PD-L1 Expression as Prognostic Indicators in a Low Prevalence of HPV-Associated Oropharyngeal Squamous Cell Carcinoma.
查看英文原题
CD8+ T Cells and PD-L1 Expression as Prognostic Indicators in a Low Prevalence of HPV-Associated Oropharyngeal Squamous Cell Carcinoma.
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研究概要
在 OPSCC 中，p16 阳性与 CD8⁺ TIL 密度与更优的 OS 相关，而 PD-L1 状态与 OS 无显著相关。
中文摘要
探讨p16、CD8⁺ TIL和PD-L1的表达，以及它们作为OPSCC患者总生存期（OS）预后指标的价值。
从病历和国家登记系统收集2012至2018年确诊OPSCC患者的数据。复核所有可获得的玻片及p16、CD8和PD-L1免疫组织化学（IHC）玻片。根据PD-L1和CD8⁺ TIL表达模式，将TME分为四型。采用Kaplan–Meier法和Cox回归模型分析OS。
160例OPSCC患者中，27例（16.88%）p16阳性。p16阳性组和PD-L1阳性组的CD8⁺ TIL密度较高（p=0.005和0.039）；但p16与PD-L1状态无相关性。p16和CD8⁺ TIL是OS改善的显著预后因素（p=0.007和0.001），PD-L1状态则不是（p=0.317）。四种TME类型中，癌组织主要呈IV型TME（PD-L1⁻/TIL⁺），而I型TME（PD-L1⁺/TIL⁺）OPSCC患者生存结局最佳。
OPSCC中p16阳性及CD8⁺ TIL密度较高与OS改善相关，而PD-L1状态与OS无显著关联。与其他TME类型相比，I型TME（PD-L1⁺/TIL⁺）OPSCC预后最佳。
展开英文摘要原文
Explore the expression p16, CD8+ TIL, and PD-L1 and its value as prognostic indicators for overall survival (OS) in patients with OPSCC.
Data from patients with OPSCC diagnosed from 2012 to 2018 were recovered from medical records and national registry. All available glass slides and slides of immunohistochemistry (IHC) of p16, CD8, and PD-L1 were reviewed. The TME was classified into four types according to the expression pattern of PD-L1 and CD8+TIL. Overall survival (OS) was assessed using the Kaplan-Meier method and Cox regression model analysis.
In 160 OPSCC patients, p16 was positive in 27 (16.88%). The density of CD8+ TIL was higher in the p16+ and PD-L1+ groups ( p = 0.005, 0.039); however, there was no association between p16 and the status of PD-L1. P16 and CD8+ TIL were significant prognostic factors for better OS ( p = 0.007, 0.001), but not PD-L1 status ( p = 0.317). Among the four types of TME, carcinoma showed mainly type IV TME (PD-L1-/TIL+), while OPSCCs with type I TME (PD-L1+/TIL+) had the best survival outcome.
The positivity of p16 and the density of CD8+ TIL were associated with better OS in OPSCC, while the status of PD-L1 was not significantly related to OS. OPSCC with type I TME (PD-L1+/TIL+) showed the best prognosis of all types of TME.
论文信息
- 作者
- Atipas K、Laokulrath N、Petsuksiri J、Ratanaprasert N、Pongsapich W
- 单位
- Department of Otorhinolaryngology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.Thailand
- 文献类型
- 非美国政府资助研究
- 期刊
- Current oncology (Toronto, Ont.)2023 Jan 20
- 原文标识
- PubMed 36826072 · DOI 10.3390/curroncol30020111
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