CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题：Immunotherapeutic Approaches in Ovarian Cancer.
Immunotherapeutic Approaches in Ovarian Cancer.
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卵巢癌（OC）是一种妇科恶性肿瘤，其诊断和治疗不断进步。基于新一代测序（NGS）的诊断已成为识别癌症研究中相关分子和通路的新方法。NGS在OC研究中的应用不断扩展，可用于早期检测、识别异常基因及失调通路，并全面描绘转录组特征，包括融合基因、基因突变和基因表达谱。随着NGS诊断的发展，OC治疗策略，如分子靶向治疗和免疫治疗，也取得进展。免疫疗法对许多其他癌症有效，其治疗OC的疗效也已在临床阶段得到证实。本综述介绍若干用于识别OC治疗靶点的NGS应用，并概述目前用于OC有效诊断和治疗的免疫治疗策略，包括疫苗、免疫检查点抑制剂和CAR-T 细胞移植。
Ovarian cancer (OC) is gynecological cancer, and diagnosis and treatment are continuously advancing. Next-generation sequencing (NGS)-based diagnoses have emerged as novel methods for identifying molecules and pathways in cancer research. The NGS-based applications have expanded in OC research for early detection and identification of aberrant genes and dysregulation pathways, demonstrating comprehensive views of the entire transcriptome, such as fusion genes, genetic mutations, and gene expression profiling.
Coinciding with advances in NGS-based diagnosis, treatment strategies for OC, such as molecular targeted therapy and immunotherapy, have also advanced. Immunotherapy is effective against many other cancers, and its efficacy against OC has also been demonstrated at the clinical phase.
In this review, we describe several NGS-based applications for therapeutic targets of OC, and introduce current immunotherapeutic strategies, including vaccines, checkpoint inhibitors, and chimeric antigen receptor (CAR)-T cell transplantation, for effective diagnosis and treatment of OC.
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