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一项力作提供对 CD19-CAR-T 细胞耐药机制的新见解

英文原题:A tour de force provides novel insights into CD19-CAR T cell resistance mechanisms.

查看英文原题

A tour de force provides novel insights into CD19-CAR T cell resistance mechanisms.

PubMed 2023/02/21(内容时间) Cell Rep Med Q1 · IF 14(JCR 2025)

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中文摘要

Sworder 等人¹开发了一种整合式同步肿瘤与效应细胞分析(STEP)方法,用于研究大 B 细胞淋巴瘤中 CD19-CAR-T 细胞治疗的耐药机制。该研究提供了新的生物学见解,并为未来的干预策略奠定了基础。

展开英文摘要原文

Sworder et al. 1 developed an integrated simultaneous tumor and effector profiling (STEP) approach to study resistance mechanisms to CD19-CAR T cell therapy in large B-cell lymphomas. Their study provides novel biological insights and paves the way for future interventions.

论文信息

作者
Talleur AC、Gottschalk S
第一作者单位
Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN, USA.United States
通讯作者单位
Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN, USA. Electronic address: stephen.gottschalk@stjude.org.United States
期刊
Cell reports. Medicine2023 Feb 21
原文标识
PubMed 36812888 · DOI 10.1016/j.xcrm.2023.100949