伴或不伴传统危险因素的口腔鳞状细胞癌患者中 PD-L1 表达与 CD8+ TILs 的预后价值及临床病理状态

英文原题：Prognostic value and clinicopathological status of PD-L1 expression and CD8+ TILs in oral squamous cell cancer patients with or without traditional risk factors.

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Prognostic value and clinicopathological status of PD-L1 expression and CD8+ TILs in oral squamous cell cancer patients with or without traditional risk factors.

PubMed 2023/02/21（内容时间） Head Neck Q1 · IF 2.2（JCR 2025）

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研究概要

NSNDNB 状态与 PD-L1 表达相关，与 CD8+ TILs 浸润无关。

中文摘要

背景

不吸烟、不饮酒且不咀嚼槟榔（NSNDNB）的口腔鳞状细胞癌（OSCC）患者生存结局较差。研究提出，可根据PD-L1表达及CD8⁺TIL（肿瘤浸润淋巴细胞）比例确定肿瘤微环境特征，并将其作为预后指标。

方法

对64例患者的OSCC样本进行免疫组织化学染色，并对PD-L1和CD8⁺ TIL评分后分为四组。采用Cox回归模型分析无病生存期（DFS）。

结果

NSNDNB患者的OSCC与女性、T1–2分类及PD-L1阳性相关。CD8⁺ TIL较少与神经周围侵犯相关；CD8⁺ TIL较多则与DFS改善相关。PD-L1阳性与DFS无相关性。IV型肿瘤微环境的DFS最高（85%）。

结论

NSNDNB状态与PD-L1表达有关，而与CD8⁺ TIL浸润无关。IV型肿瘤微环境与最佳DFS相关。CD8⁺ TIL较多的患者生存更好，而单独的PD-L1阳性与DFS无关。

展开英文摘要原文

BACKGROUND

Non-smokers, non-drinkers, and non-betel quid chewers (NSNDNBs) with oral squamous cell carcinoma (OSCC) have poor survival outcomes. Tumor microenvironment based on PD-L1/CD8+ T cell infiltrated lymphocyte (TIL) proportion is proposed as a prognostic indicator.

METHODS

Immunohistochemistry staining was performed on OSCC samples from 64 patients. The PD-L1/CD8+ TILs were scored and stratified into four groups. Disease-free survival (DFS) was analyzed using a Cox regression model.

RESULTS

OSCC in NSNDNB patients was associated with female sex, T1-2 classification, and PD-L1 positivity. Low CD8+ TILs correlated with perineural invasion. High CD8+ TILs correlated with improved DFS. PD-L1 positivity was not correlated with DFS. Type IV tumor microenvironment yielded the highest DFS (85%).

CONCLUSION

NSNDNB status relates to PD-L1 expression regardless of CD8+ TILs infiltration. Type IV tumor microenvironment was associated with the best DFS. High CD8+ TILs resulted in better survival, while PD-L1 positivity alone was not correlated to DFS.

论文信息

作者: Soopanit T、Laokulrath N、Chayopasakul V、Pongsapich W
第一作者单位: Department of Otorhinolaryngology, Chulabhorn Hospital, Bangkok, Thailand.Thailand
通讯作者单位: Department of Otorhinolaryngology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.Thailand
文献类型: 非美国政府资助研究
期刊: Head & neck2023 Apr

原文标识: PubMed 36811208　·　DOI 10.1002/hed.27330

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