CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题：Research progress of neoantigen-based dendritic cell vaccines in pancreatic cancer.
Research progress of neoantigen-based dendritic cell vaccines in pancreatic cancer.
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肿瘤抑制基因或癌基因等关键基因的突变在肿瘤的发生和发展中发挥重要作用。肿瘤细胞基因组中的非同义突变将产生非自身蛋白（新抗原），通过激活CD4+和CD8+ T细胞来激活免疫系统。基于新抗原的肽疫苗在单独或与其他治疗策略联合治疗多种癌症方面已展现出令人兴奋的治疗效果。此外，负载抗原的DC疫苗在诱导更强免疫应答方面比由抗原和佐剂生成的疫苗更为有效。因此，基于新抗原的树突状细胞（DC）疫苗可能在对抗某些恶性肿瘤方面取得有前景的疗效。在这篇综述中，我们总结并讨论了新抗原、基于新抗原的疫苗以及基于DC的疫苗在胰腺癌（PCs）中的近期研究进展。同时也重点阐述了新抗原与基于DC的疫苗在PC中的联合应用。因此，我们的工作将为促进针对PC的个性化基于新抗原的DC疫苗的开发提供更详细的证据和新的观点。
The mutation of the crucial genes such as tumor suppressors or oncogenes plays an important role in the initiation and development of tumors. The non-synonymous mutations in the tumor cell genome will produce non-autologous proteins (neoantigen) to activate the immune system by activating CD4+ and CD8+ T cells. Neoantigen-based peptide vaccines have exhibited exciting therapeutic effects in treating various cancers alone or in combination with other therapeutic strategies.
Furthermore, antigen-loaded DC vaccines are more powerful in inducing stronger immune responses than vaccines generated by antigens and adjuvants.
Therefore, neoantigen-based dendritic cell (DC) vaccines could achieve promising effects in combating some malignant tumors. In this review, we summarized and discussed the recent research progresses of the neoantigen, neoantigen-based vaccines, and DC-based vaccine in pancreatic cancers (PCs). The combination of the neoantigen and DC-based vaccine in PC was also highlighted.
Therefore, our work will provide more detailed evidence and novel opinions to promote the development of a personalized neoantigen-based DC vaccine for PC.
在 PubMed 查看 → 出版商原文（DOI） 全文 PDF（PMC）· 可下载 治疗专题与资料阅读指南 资料来源与翻译说明 报告译文或资料问题 →
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