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肿瘤免疫治疗的进展

英文原题:Advancements in Cancer Immunotherapies.

查看英文原题

Advancements in Cancer Immunotherapies.

PubMed 2022/12/27(内容时间) Vaccines (Basel) Q2 · IF 3.5(JCR 2025)

分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。

中文摘要

近期研究提示,免疫系统参与了以肿瘤微环境为特定靶点的生物疗法。利用免疫细胞治疗恶性肿瘤已取得显著进展,其中在细胞介导免疫中发挥关键作用的T细胞尤为重要,并已在临床试验中显示疗效。因此,本文聚焦肿瘤治疗的相关治疗方法与开发策略。本综述重点讨论免疫调节反应、关键肿瘤浸润细胞的作用、作用机制以及预后生物标志物,并介绍治疗策略的最新进展。

展开英文摘要原文

Recent work has suggested involvement of the immune system in biological therapies specifically targeting tumor microenvironment. Substantial advancement in the treatment of malignant tumors utilizing immune cells, most importantly T cells that play a key role in cell-mediated immunity, have led to success in clinical trials.

Therefore, this article focuses on the therapeutic approaches and developmental strategies to treat cancer. This review emphasizes the immunomodulatory response, the involvement of key tumor-infiltrating cells, the mechanistic aspects, and prognostic biomarkers.

We also cover recent advancements in therapeutic strategies.

论文信息

作者
Roy R、Singh SK、Misra S
单位
UICentre for Drug Discovery, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60607, USA.United States
文献类型
综述
期刊
Vaccines2022 Dec 27
原文标识
PubMed 36679904 · DOI 10.3390/vaccines11010059