CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
仁者见仁：眼部超声增强监测 CAR-T 细胞治疗后的神经毒性
英文原题：It Is in the Eye of the Beholder: Ocular Ultrasound Enhanced Monitoring of Neurotoxicity after CAR-T Cell Therapy.
查看英文原题
It Is in the Eye of the Beholder: Ocular Ultrasound Enhanced Monitoring of Neurotoxicity after CAR-T Cell Therapy.
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中文摘要
通常用于急诊环境中的床旁超声测量视神经鞘直径有助于诊断颅内压升高。我们报告一例26岁男性，因复发弥漫大B细胞淋巴瘤接受Axicabtagene Ciloleucel CAR-T 细胞治疗而住院，出现免疫效应细胞相关神经毒性综合征的进行性症状。眼底检查提示视盘边缘模糊。床旁眼部超声显示双侧视神经鞘直径增宽及视盘膨出。患者放置脑室造瘘管进行监测，并接受类固醇和甘露醇治疗，以及tocilizumab。在ICU治疗7天后，患者恢复，无长期神经功能缺损证据。
展开英文摘要原文
Usually used in emergency settings, bedside sonographic measurement of optic nerve sheath diameter can aid in diagnosing elevated intracranial pressure.
We report a case of a 26-year-old male hospitalized for CAR T-cell therapy with Axicabtagene Ciloleucel for treatment of relapsed diffuse large B-cell lymphoma, who developed progressive symptoms of immune effector cell-associated neurotoxicity syndrome. Fundoscopic examination suggested the presence of blurred optic disc margins.
Bedside ocular ultrasound revealed wide optic nerve sheath diameters and bulging optic discs bilaterally. The patient had a ventriculostomy placed for monitoring and received treatment with steroids and mannitol, as well as tocilizumab. After 7 days in the ICU, the patient recovered with no evidence of long-term neurological deficits.
论文信息
- 作者
- Garcia-Robledo JE、Valencia-Sanchez C、Knox MG、Goodman BP、Rosenthal AC、Patel B、Castro JE
- 单位
- Division of Hematology/Oncology, Mayo Clinic, Phoenix, AZ 85054, USA.United States
- 文献类型
- 病例报告
- 期刊
- Hematology reports2022 Dec 29
- 原文标识
- PubMed 36648879 · DOI 10.3390/hematolrep15010001
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