不适合移植的大 B 细胞淋巴瘤二线使用 axicabtagene ciloleucel：ALYCANTE 最终分析
Second-line axicabtagene ciloleucel in large B-cell lymphoma ineligible for transplantation: ALYCANTE final analysis.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
成熟 T 细胞和 NK 细胞淋巴瘤：分子遗传学特征的最新进展
英文原题：Mature T-cell and NK-cell lymphomas: updates on molecular genetic features.
查看英文原题
Mature T-cell and NK-cell lymphomas: updates on molecular genetic features.
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中文摘要
成熟T细胞和NK细胞淋巴瘤是一组异质性罕见且通常具有侵袭性的肿瘤。其诊断和亚分类历来主要依赖于临床、组织学和免疫表型特征的整合，而这些特征常常相互重叠。近年来各种基因组技术的广泛应用为这些疾病的病理生物学提供了广泛的见解，使得更精确的诊断分类、改进的预后判断以及新疗法的开发成为可能。在本综述中，我们总结了最常见的成熟T细胞和NK细胞淋巴瘤类型的基因组特征，特别关注基因组学在最近发布的国际共识和更新的世界卫生组织分类系统背景下对生物学见解、分类、风险分层和选择疗法的贡献。
展开英文摘要原文
Mature T-cell and NK-cell lymphomas are a heterogeneous group of rare and typically aggressive neoplasms. Diagnosis and subclassification have historically relied primarily on the integration of clinical, histologic, and immunophenotypic features, which often overlap. The widespread application of a variety of genomic techniques in recent years has provided extensive insight into the pathobiology of these diseases, allowing for more precise diagnostic classification, improved prognostication, and development of novel therapies.
In this review, we summarize the genomic features of the most common types of mature T-cell and NK-cell lymphomas with a particular focus on the contribution of genomics to biologic insight, classification, risk stratification, and select therapies in the context of the recently published International Consensus and updated World Health Organization classification systems.
论文信息
- 作者
- Lewis NE、Sardana R、Dogan A
- 单位
- Hematopathology Service, Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA. lewisn1@mskcc.org.United States
- 文献类型
- 综述
- 期刊
- International journal of hematology2023 Apr
- 原文标识
- PubMed 36637656 · DOI 10.1007/s12185-023-03537-7