CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
局部区域 CAR-T 细胞治疗儿童中枢神经系统肿瘤：临床操作流程与导管安全性
英文原题：Locoregional CAR T cells for children with CNS tumors: Clinical procedure and catheter safety.
查看英文原题
Locoregional CAR T cells for children with CNS tumors: Clinical procedure and catheter safety.
分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。
中文摘要
中枢神经系统（CNS）肿瘤是儿童中最常见的实体恶性肿瘤。过继细胞疗法已成功治疗儿童白血病，且在儿童CNS肿瘤临床前研究中显示疗效；据此，嵌合抗原受体（CAR）T细胞有望改善复发性肿瘤及弥漫性内生性脑桥胶质瘤（DIPG）等通常致命疾病的治疗结局。然而，脑和脊髓肿瘤治疗的一大障碍，是T细胞无法有效趋化至病灶。目前多项早期临床试验正在研究通过颅内导管输注、进行局部区域CAR-T 细胞递送的方式。本文介绍西雅图儿童医院单中心经验，包括为儿童成功、重复实施颅内T细胞输注所需的多学科流程，以及307次颅内CAR-T 细胞给药中的导管相关安全性。
展开英文摘要原文
Central nervous system (CNS) tumors are the most common solid malignancy in the pediatric population. Based on adoptive cellular therapy's clinical success against childhood leukemia and the preclinical efficacy against pediatric CNS tumors, chimeric antigen receptor (CAR) T cells offer hope of improving outcomes for recurrent tumors and universally fatal diseases such as diffuse intrinsic pontine glioma (DIPG).
However, a major obstacle for tumors of the brain and spine is ineffective T cell chemotaxis to disease sites. Locoregional CAR T cell delivery via infusion through an intracranial catheter is currently under study in multiple early phase clinical trials.
Here, we describe the Seattle Children's single-institution experience including the multidisciplinary process for the preparation of successful, repetitive intracranial T cell infusion for children and the catheter-related safety of our 307 intracranial CAR T cell doses.
论文信息
- 作者
- Vitanza NA、Ronsley R、Choe M、Henson C、Breedt M、Barrios-Anderson A、Wein A、Brown C
- 单位
- Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA, USA; Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA, USA; Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA, USA. Electronic address: nicholas.vitanza@seattlechildrens.org.United States
- 文献类型
- 美国 NIH 资助研究 · 非美国政府资助研究
- 期刊
- Neoplasia (New York, N.Y.)2023 Feb
- 原文标识
- PubMed 36599192 · DOI 10.1016/j.neo.2022.100870
在 PubMed 查看 → 出版商原文（DOI） 全文 PDF（PMC）· 可下载 治疗专题与资料阅读指南 资料来源与翻译说明 报告译文或资料问题 →