间皮素作为癌症免疫治疗的生物标志物和治疗靶点
Mesothelin as Biomarker and Therapeutic Target for Immunotherapy in Cancer.
癌症仍是一个关键的全球健康问题，原因在于发现晚、耐药和高死亡率。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
胃癌中 TIL（肿瘤浸润淋巴细胞）与程序性死亡配体 1（PD-L1）表达的预后作用及临床意义：系统综述与荟萃分析
英文原题：Prognostic role and clinical significance of tumor-infiltrating lymphocyte (TIL) and programmed death ligand 1 (PD-L1) expression in gastric cancer: a systematic review and meta-analysis.
查看英文原题
Prognostic role and clinical significance of tumor-infiltrating lymphocyte (TIL) and programmed death ligand 1 (PD-L1) expression in gastric cancer: a systematic review and meta-analysis.
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研究概要
该研究显示 PD-L1 和 TILs 在胃癌患者中无预后作用。
研究思路结论见上方概要
背景
本研究旨在评估程序性死亡配体1（PD-L1）和TIL（肿瘤浸润淋巴细胞）（TILs）对胃癌患者生存的预后影响及其与临床病理特征的相关性。
方法
检索了PubMed、Scopus、ProQuest、Web of Science和Ovid数据库以获取相关研究。本研究共纳入11项研究，涉及2298例患者。
结果
与TILs水平一样，PD-L1表达与TNM分期、淋巴结转移、血管侵犯和肿瘤位置之间无显著关联（所有p值0.05）。此外，PD-L1表达与总生存期（OS）（HR = 0.76，95% CI：0.55至1.05，p值 = 0.10）和无病生存期（DFS）（HR = 0.62，95% CI：0.10至3.68，p值 = 0.59）之间无显著关联。在评估TILs存在与生存关联时，分析显示TILs存在与总生存期（OS）之间无关联（HR = 0.95，95% CI：0.62至1.45）。
展开英文摘要原文
BACKGROUND AND OBJECTIVE
This study intended to evaluate the prognostic effects of programmed death-ligand 1 (PD-L1) and tumor-infiltrating lymphocytes (TILs) in survival and their associations with clinicopathological characteristics in patients with gastric cancer.
METHODS
PubMed, Scopus, ProQuest, Web of Science, and Ovid databases were searched to obtain the relevant studies. Eleven studies with 2298 patients were included in this study.
RESULTS
Like the level of TILs, there were no significant associations between PD-L1 expression and TNM stage, lymph node metastasis, vascular invasion, and tumor location (All p values 0.05). Furthermore, there was no significant association between PD-L1 expression with overall survival (OS) (HR = 0.76, 95% CI: 0.55 to 1.05, p value = 0.10) and disease-free survival (DFS) (HR = 0.62, 95% CI: 0.10 to 3.68, p value = 0.59). In the assessment of TILs presence and survival association, the analysis showed no association between TILs presence and overall survival (OS) (HR = 0.95, 95% CI: 0.62 to 1.45).
CONCLUSIONS
In conclusion, the study has revealed no prognostic effect of PD-L1 and TILs in gastric cancer patients.
论文信息
- 作者
- Ren J、He Q、Yin H、Zheng L、Li L、Wu X
- 第一作者单位
- Department of Gastroenterology, General Hospital of Western Theater Command, Chengdu, 610083, China.China
- 通讯作者单位
- Department of Gastroenterology, General Hospital of Western Theater Command, Chengdu, 610083, China. wxllady@163.com.China
- 文献类型
- 荟萃分析 · 系统综述
- 期刊
- Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2023 May
- 原文标识
- PubMed 36528835 · DOI 10.1007/s12094-022-03040-1