间皮素作为癌症免疫治疗的生物标志物和治疗靶点
Mesothelin as Biomarker and Therapeutic Target for Immunotherapy in Cancer.
癌症仍是一个关键的全球健康问题，原因在于发现晚、耐药和高死亡率。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
胃癌与免疫系统：改善预后的关键？
英文原题：Gastric Cancer and the Immune System: The Key to Improving Outcomes?
查看英文原题
Gastric Cancer and the Immune System: The Key to Improving Outcomes?
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中文摘要
胃腺癌是最常见的胃癌类型，也是一种起源于胃上皮、致死率很高的癌症。胃癌常在晚期才被诊断，且死亡率较高，因此一直是医学界重点关注的疾病。手术和化疗仍是主要治疗方法，但免疫疗法在其他恶性肿瘤中显示出前景，也受到越来越多关注。随着对免疫系统在胃癌发生和生长中作用的认识加深，免疫治疗的定位也日益明确。目前，多种旨在增强免疫系统的治疗方法正在临床试验中评估，包括免疫检查点抑制剂、抗体药物偶联物和免疫细胞疗法。本文综述胃癌的免疫图景及相关免疫治疗策略。
展开英文摘要原文
Gastric adenocarcinoma is by far the most common form of gastric cancer (GC) and is a highly lethal form of cancer arising from the gastric epithelium. GC is an important area of focus of the medical community, given its often late-stage of diagnosis and associated high mortality rate. While surgery and chemotherapy remain the primary treatments, attention has been drawn to the use of immunologic therapies, which have shown promise in the treatment of other malignancies.
The role for immune-based therapies has become clearer as we obtain a greater understanding of the role of the immune system in gastric cancer formation and growth. A variety treatment to augment the immune system are under evaluation in clinical trials, and these include immune checkpoint inhibitors, antibody-drug conjugates, and immune cell-based therapies.
Here, we review the immune landscape and immune-based therapies for GC.
论文信息
- 作者
- Keshavjee SH、Moy RH、Reiner SL、Ryeom SW、Yoon SS
- 单位
- Division of Surgical Oncology, Department of Surgery, Columbia University Irving Medical Center, New York, NY 10032, USA.United States
- 文献类型
- 综述
- 期刊
- Cancers2022 Nov 30
- 原文标识
- PubMed 36497422 · DOI 10.3390/cancers14235940
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