黏膜相关恒定 T 细胞用于肿瘤免疫治疗

英文原题：Mucosal-associated invariant T cells for cancer immunotherapy.

查看英文原题

Mucosal-associated invariant T cells for cancer immunotherapy.

PubMed 2022/12/05（内容时间） Mol Ther Q1 · IF 11.4（JCR 2025）

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中文摘要

人类黏膜相关恒定T（MAIT）细胞的特征是表达恒定的TCR α链Vα7.2-Jα33/Jα20/Jα12，并与受限的TCR β链配对。MAIT细胞识别由高度保守的MHC I类样分子MR1呈递的微生物肽，并桥接固有免疫和获得性免疫系统以介导增强的免疫应答。激活后，MAIT细胞迅速增殖，产生多种细胞因子和细胞毒性分子，并触发有效的抗肿瘤免疫。给予代表性的MAIT细胞配体5-OP-RU可有效激活MAIT细胞并增强其抗肿瘤能力。在这篇综述中，我们介绍MAIT细胞生物学及其在抗肿瘤免疫中的重要性，总结目前用于癌症治疗的外周血单核细胞来源和干细胞来源的MAIT细胞产品的开发进展，并讨论MAIT细胞基因工程用于现货型癌症免疫治疗的潜力。

展开英文摘要原文

Human mucosal-associated invariant T (MAIT) cells are characterized by their expression of an invariant TCR α chain Vα7. 2-Jα33/Jα20/Jα12 paired with a restricted TCR β chain. MAIT cells recognize microbial peptides presented by the highly conserved MHC class I-like molecule MR1 and bridge the innate and acquired immune systems to mediate augmented immune responses. Upon activation, MAIT cells rapidly proliferate, produce a variety of cytokines and cytotoxic molecules, and trigger efficient antitumor immunity.

Administration of a representative MAIT cell ligand 5-OP-RU effectively activates MAIT cells and enhances their antitumor capacity. In this review, we introduce MAIT cell biology and their importance in antitumor immunity, summarize the current development of peripheral blood mononuclear cell-derived and stem cell-derived MAIT cell products for cancer treatment, and discuss the potential of genetic engineering of MAIT cells for off-the-shelf cancer immunotherapy.

论文信息

作者: Li YR、Zhou K、Wilson M、Kramer A、Zhu Y、Dawson N、Yang L
第一作者单位: Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA.United States
通讯作者单位: Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: liliyang@ucla.edu.United States
文献类型: 综述 · 非美国政府资助研究
期刊: Molecular therapy : the journal of the American Society of Gene Therapy2023 Mar 1

原文标识: PubMed 36463401　·　DOI 10.1016/j.ymthe.2022.11.019

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