工程化益生菌用于肿瘤靶向联合化学免疫治疗
Engineered probiotics for tumor-targeted combination chemoimmunotherapy.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
用于癌症免疫治疗的细胞递送装置
英文原题：Cell delivery devices for cancer immunotherapy.
查看英文原题
Cell delivery devices for cancer immunotherapy.
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中文摘要
利用同种异体或自体免疫细胞的过继细胞疗法（ACT）在靶向癌症治疗中具有巨大前景。尽管ACT在治疗血液系统恶性肿瘤方面取得了巨大成功，但通过静脉输注免疫细胞来根除实体瘤的疗效仍然有限。随着癌症免疫治疗技术的不断拓展，人们探索了新型递送策略，通过创新给药途径、维持细胞活力以及使肿瘤微环境正常化，来提高过继转移细胞治疗实体瘤的治疗效力。在本综述中，总结了多种用于细胞递送的装置。同时讨论了用于癌症免疫治疗的细胞递送装置的前景与挑战。
展开英文摘要原文
Adoptive cell therapy (ACT) that leverages allogeneic or autologous immune cells holds vast promise in targeted cancer therapy. Despite the tremendous success of ACT in treating hematopoietic malignancies, its efficacy is limited in eradicating solid tumors via intravenous infusion of immune cells.
With the extending technology of cancer immunotherapy, novel delivery strategies have been explored to improve the therapeutic potency of adoptively transferred cells for solid tumor treatment by innovating the administration route, maintaining the cell viability, and normalizing the tumor microenvironment. In this review, a variety of devices for cell delivery are summarized. Perspectives and challenges of cell delivery devices for cancer immunotherapy are also discussed.
论文信息
- 作者
- Wen P、Wu W、Wang F、Zheng H、Liao Z、Shi J、Zhu C、Zhao P
- 第一作者单位
- Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.China
- 通讯作者单位
- Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China; Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou 311121, China; Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China; Jinhua Institute of Zhejiang University, Jinhua 321299, China; MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China. Electronic address: guzhen@zju.edu.cn.China
- 文献类型
- 综述 · 非美国政府资助研究
- 期刊
- Journal of controlled release : official journal of the Controlled Release Society2023 Jan
- 原文标识
- PubMed 36442617 · DOI 10.1016/j.jconrel.2022.11.041