CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
波兰 CAR-T 细胞发展的现状与未来展望
英文原题：Current and Future Perspectives for Chimeric Antigen Receptor T Cells Development in Poland.
查看英文原题
Current and Future Perspectives for Chimeric Antigen Receptor T Cells Development in Poland.
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中文摘要
CAR-T（CAR-T）细胞是经过基因修饰的自体T细胞，已经彻底改变了复发/难治性血液系统恶性肿瘤的治疗。在这篇综述中，我们介绍了参与CAR-T 细胞激活的分子通路，详细描述了目前已在欧盟获批用于临床实践的CAR-T 细胞的受体结构和生物学活性，并解释了它们之间的功能差异。最后，我们介绍了CAR-T 细胞在波兰的发展潜力，并指出了该领域未来研究的可能方向，包括CAR-T 细胞和CAR-自然杀伤（NK）细胞的新修饰和应用。
展开英文摘要原文
Chimeric antigen receptor T (CAR-T) cells are genetically modified autologous T cells that have revolutionized the treatment of relapsing and refractory haematological malignancies. In this review we present molecular pathways involved in the activation of CAR-T cells, describe in details the structures of receptors and the biological activity of CAR-T cells currently approved for clinical practice in the European Union, and explain the functional differences between them.
Finally, we present the potential for the development of CAR-T cells in Poland, as well as indicate the possible directions of future research in this area, including novel modifications and applications of CAR-T cells and CAR-natural killer (NK) cells.
论文信息
- 作者
- Ślebioda TJ、Stanisławowski M、Kaszubowska L、Zaucha JM、Żmijewski MA
- 单位
- Department of Histology, Medical University of Gdańsk, Dębinki 1, 80-210 Gdańsk, Poland.Poland
- 文献类型
- 综述
- 期刊
- Biomedicines2022 Nov 13
- 原文标识
- PubMed 36428480 · DOI 10.3390/biomedicines10112912
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