CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题：Monocytes: A Promising New TRAIL in Ovarian Cancer Cell Therapy.
Monocytes: A Promising New TRAIL in Ovarian Cancer Cell Therapy.
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腹腔内给予铂耐药卵巢癌患者过继性输注IFN激活的单核细胞，显示出抗肿瘤效应和可接受的耐受性。单核细胞暴露于IFNα和IFNγ后上调TRAIL，从而触发caspase 8及直接细胞间接触依赖性的卵巢癌细胞凋亡。参见Green等人的相关文章，第349页。
Adoptive cell transfer of IFN-activated monocytes administered intraperitoneally to patients with platinum-resistant ovarian cancer demonstrated antitumor effects and acceptable tolerability. The exposure of monocytes to IFNα and IFNγ upregulated TRAIL, which triggered caspase 8 and direct cell-to-cell contact-dependent apoptosis of ovarian cancer cells. See related article by Green et al., p. 349.
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