CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
接受 CAR-T 细胞治疗患者中尖端赛多孢子菌引起的鹰嘴滑囊炎
英文原题：Olecranon bursitis caused by Scedosporium apiospermum in a patient treated with CAR-T cells.
查看英文原题
Olecranon bursitis caused by Scedosporium apiospermum in a patient treated with CAR-T cells.
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中文摘要
嵌合抗原受体（CAR）T 细胞疗法是一种较新的血液系统恶性肿瘤免疫疗法。尽管 CAR-T 治疗后患者感染风险增加，真菌感染的报道仍较少。我们报告一例淋巴瘤患者接受 CAR-T 治疗后发生 Scedosporium apiospermum 感染并导致肘部滑囊炎。该真菌性滑囊炎在泊沙康唑治疗期间复发，但经手术切除滑囊后治愈。
展开英文摘要原文
Chimeric antigen receptor (CAR-) T cell therapy is a relatively new form of immunotherapy for hematological malignancies. Although patients are at increased risk of infection following CAR-T cell therapy, reports of fungal infections are scarce.
We report a case of Scedosporium apiospermum infection causing bursitis of the elbow in a lymphoma patient after treatment with CAR-T cells. The fungal bursitis relapsed under posaconazole treatment, but was cured after surgical extirpation of the bursa.
论文信息
- 作者
- Falkenburg WJJ、Jalink M、Kersten MJ、Buil JB、van Dijk K
- 单位
- Department of Medical Microbiology and Infection Control, Amsterdam University Medical Centers, Amsterdam, the Netherlands.Netherlands
- 文献类型
- 病例报告
- 期刊
- Medical mycology case reports2022 Dec
- 原文标识
- PubMed 36353268 · DOI 10.1016/j.mmcr.2022.10.002
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