工程化益生菌用于肿瘤靶向联合化学免疫治疗
Engineered probiotics for tumor-targeted combination chemoimmunotherapy.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
实体瘤中的 CAR 细胞设计策略
英文原题：CAR cell design strategies in solid tumors.
查看英文原题
CAR cell design strategies in solid tumors.
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中文摘要
除嵌合抗原受体（CAR）-T细胞疗法外，CAR-NK、CAR-NKT、CAR-M和CAR-T 细胞疗法已逐渐应用于实体瘤的治疗。与血液系统肿瘤相比，实体瘤具有肿瘤异质性强、靶抗原选择有限、T细胞浸润低以构建免疫抑制性肿瘤微环境等特点。这些特征给CAR细胞疗法带来了巨大障碍。本文全面分析了不同CAR细胞在实体瘤中的应用，并总结了不同CAR细胞的设计原则，为CAR细胞疗法在实体瘤中的发展提供方向。
展开英文摘要原文
In addition to chimeric antigen receptor (CAR)- T-cell therapy, CAR-NK, CAR-NKT, CAR-M and CAR- T-cell therapy have gradually been applied to the treatment of solid tumors. Compared to hematological tumors, solid tumors have the characteristics of strong tumor heterogeneity, limited target antigen selection, and low T-cell infiltration to build immunosuppressive tumor microenvironment.
These features would present great obstacles to CAR cell therapy. This paper comprehensively analyzed the application of different CAR cells to solid tumors and summarized the design principles of different CAR cells to provide the direction for the development of CAR cell therapy in solid tumors.
论文信息
- 作者
- Wang L、Chen X、Zhang L、Niu B、Li L、Sun Y、Yuan X
- 第一作者单位
- Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jie Fang Road 1095, Wuhan, Hubei, China.China
- 通讯作者单位
- Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jie Fang Road 1095, Wuhan, Hubei, China. Electronic address: yuanxianglin@hust.edu.cn.China
- 文献类型
- 综述
- 期刊
- International immunopharmacology2022 Dec
- 原文标识
- PubMed 36272358 · DOI 10.1016/j.intimp.2022.109345