CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
不适合移植但符合 CAR-T 细胞治疗条件：一个真实且相关的人群
英文原题：Transplant-ineligible but chimeric antigen receptor T-cells eligible: a real and relevant population.
查看英文原题
Transplant-ineligible but chimeric antigen receptor T-cells eligible: a real and relevant population.
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中文摘要
自体干细胞移植（ASCT）和嵌合抗原受体（CAR）T细胞是复发/难治性弥漫大B细胞淋巴瘤的两种治疗选择。两者均为强化且可能具有治愈性的治疗，但在疗效和毒性方面存在差异。ASCT可提供给化疗敏感的“适合”患者（即通常年轻且合并症有限）。另一方面，真实世界研究表明，CAR-T 细胞可安全用于体能状态较差和老年患者。因此，存在一个可能相当可观的患者群体，尽管不适合ASCT，但仍可能接受CAR-T 细胞治疗。随着ASCT和CAR-T 细胞相对角色的演变，识别和定义这一群体可能日益重要。在此，我们综述可能有助于识别这一“不适合ASCT但适合CAR-T 细胞”患者群体的标准。
展开英文摘要原文
Autologous stem cell transplantation (ASCT) and chimeric antigen receptor (CAR) T-cells are two therapeutic options for relapsed/refractory diffuse large B-cell lymphoma. Both are intensive and potentially curative therapies but differ in their efficacy and toxicity. ASCT may be offered to 'fit' patients (i. e. usually young with limited comorbidities) with chemosensitive disease. On the other hand, real world studies have shown that CAR T-cells may be safely administered to less fit and older patients.
Thus, there is a potentially significant population of patients who may be offered CAR T-cell therapy despite not being eligible for ASCT. As the relative role of ASCT and CAR T-cells evolves, recognising and defining this population may be increasingly relevant.
Here, we review criteria which may help identify this 'ASCT-ineligible but CAR T-cells eligible' population of patients.
论文信息
- 作者
- Vic S、Lemoine J、Armand P、Lemonnier F、Houot R
- 第一作者单位
- Department of Hematology, CHU de Rennes, Université de Rennes, Rennes, France.France
- 通讯作者单位
- Department of Hematology, CHU de Rennes, Université de Rennes, Rennes, France. Electronic address: roch.houot@chu-rennes.fr.France
- 文献类型
- 综述
- 期刊
- European journal of cancer (Oxford, England : 1990)2022 Nov
- 原文标识
- PubMed 36166850 · DOI 10.1016/j.ejca.2022.08.019