CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
CD4+ T 细胞作为抗肿瘤免疫介质的作用
英文原题：Roles of CD4+ T cells as mediators of antitumor immunity.
查看英文原题
Roles of CD4+ T cells as mediators of antitumor immunity.
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中文摘要
已经充分证实，CD8+ T细胞是抗肿瘤适应性免疫反应的效应细胞，而CD4+ T细胞则辅助或抑制CD8+细胞毒性T细胞的生成。然而，在若干实验模型以及癌症患者中，已表明CD4+ T细胞也可以直接通过杀伤肿瘤细胞，或间接通过激活固有免疫细胞，或通过减少肿瘤血管生成来介导抗肿瘤免疫。在这篇综述中，我们讨论了越来越多的证据，表明CD4+ T细胞作为抗肿瘤免疫介质这一被低估的作用。
展开英文摘要原文
It has been well established that CD8+ T cells serve as effector cells of the adaptive immune response against tumors, whereas CD4+ T cells either help or suppress the generation of CD8+ cytotoxic T cells.
However, in several experimental models as well as in cancer patients, it has been shown that CD4+ T cells can also mediate antitumor immunity either directly by killing tumor cells or indirectly by activating innate immune cells or by reducing tumor angiogenesis. In this review, we discuss the growing evidence of this underappreciated role of CD4+ T cells as mediators of antitumor immunity.
论文信息
- 作者
- Kravtsov DS、Erbe AK、Sondel PM、Rakhmilevich AL
- 单位
- Department of Human Oncology, University of Wisconsin, Madison, WI, United States.United States
- 文献类型
- 综述 · 美国 NIH 资助研究
- 期刊
- Frontiers in immunology2022
- 原文标识
- PubMed 36159781 · DOI 10.3389/fimmu.2022.972021
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