CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题：High expression of CD8 in the tumor microenvironment is associated with PD-1 expression and patient survival in high-grade serous ovarian cancer.
High expression of CD8 in the tumor microenvironment is associated with PD-1 expression and patient survival in high-grade serous ovarian cancer.
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在单变量分析中，较高的间质 CD8+ TILs 评分与 DFS 和 OS 显著相关，而间质 CD3+和 CD4+ TILs 评分以及上皮内 CD3+、CD4+和 CD8+ TILs 评分在单变量和多变量分析中均与 DFS 和 OS 无关。此外，我们发现 PD-1 阳性与间质 CD3+ TILs 和上皮内 CD8+ TILs 评分之间存在显著关联。然而，PD-1 阳性与 HGSOC 病例的生存之间未发现显著关系。
本研究评估了高级别浆液性卵巢癌（HGSOC）中程序性死亡受体-1（PD-1）的表达以及CD3、CD4和CD8TIL（肿瘤浸润淋巴细胞）（TILs），并将我们的结果与新辅助化疗史和疾病预后相关联。
本研究纳入具有活检或手术切除材料的原发性HGSOC确诊病例。通过免疫组化评估肿瘤组织中CD3、CD4、CD8和PD1的免疫反应性。我们在预先设定的高TIL和低TIL两组中分析TIL。通过(2)检验或Fisher精确检验评估临床特征、PD-1与TIL之间的关系。我们使用Kaplan-Meier生存分析和Cox比例风险回归模型评估生存与TIL及PD1数量之间的关联。
单因素分析显示，最佳减瘤术（p<0.001）、早期国际妇产科联盟分期（p=0.046）以及肿瘤细胞中基质CD8+ TIL表达评分较高（p=0.028）均与更长的无病生存期（DFS）显著相关，而所分析的其他变量，包括PD-1阳性、基质CD3+和CD4+ TIL以及上皮内CD3+、CD4+和CD8+ TIL，均与DFS无关。此外，单因素分析显示，最佳减瘤术（p=0.010）以及肿瘤细胞中基质CD8+ TIL表达评分较高（p=0.021）均与更长的总生存期（OS）显著相关。
The current study assesses programmed death-1 (PD-1) receptor expression and CD3, CD4, and CD8 tumor-infiltrating lymphocytes (TILs) in high-grade serous ovarian cancer (HGSOC) and associates our results with neoadjuvant chemotherapy history and disease prognosis.
We included cases diagnosed with primary HGSOC with biopsy or surgical resection materials in this study. The immunoreactivity of CD3, CD4, CD8, and PD1 was assessed immunohistochemically in tumor tissue. We analyzed TILs in two predetermined groups of high and low TIL. The relationships between clinical characteristics, PD-1, and TIL were assessed. by the (2) test or Fisher's Exact test. We used Kaplan-Meier survival analysis and Cox proportional hazards regression model to the connection between survival and the amounts of TIL, and PD1.
Univariate analysis demonstrated that optimal debulking (p<0.001), early International Federation of Gynecology and Obstetrics stage (p=0.046), and higher scores of stromal CD8+ TIL expression (p=0.028) in tumor cells were all substantially correlated with longer disease-free survival (DFS), whereas the remaining variables analyzed, including PD-1 positivity, stromal CD3+, and CD4+ TILs, and intraepithelial CD3+, CD4+, and CD8+ TILs, were not correlated with DFS. Also, univariate analysis revealed that optimal debulking (p=0.010), and higher scores of stromal CD8+ TIL expression (p=0.021) in tumor cells were all substantially correlated with longer overall survival (OS).
Higher scores of stromal CD8+ TILs are substantially correlated with DFS and OS in univariate analyses, whereas scores of stromal CD3+ and CD4+ TILs, and intraepithelial CD3+, CD4+, and CD8+ TILs are not correlated with DFS and OS in both univariate and multivariate analyses. Also, we found a significant association between PD-1 positivity and the scores of stromal CD3+ TILs and intraepithelial CD8+ TILs. However, no remarkable relationship was revealed between PD-1 positivity and the survival of HGSOC cases.
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