CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
免疫细胞和受体在癌症治疗中的作用：一种免疫治疗方法
英文原题：Role of Immune Cells and Receptors in Cancer Treatment: An Immunotherapeutic Approach.
查看英文原题
Role of Immune Cells and Receptors in Cancer Treatment: An Immunotherapeutic Approach.
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中文摘要
癌症免疫疗法调节免疫系统对抗癌症的能力。由于其极其复杂性，科学家们正在努力将所有拼图碎片拼凑起来，以更清晰地了解免疫系统。现有证据的碎片显示了癌症与免疫系统之间的联系。对肿瘤和淋巴恶性肿瘤的免疫反应受B细胞、γδT细胞、NK细胞和树突状细胞（DCs）的影响。癌症免疫疗法，包括过继性癌症疗法、单克隆抗体（mAbs）、免疫检查点疗法和CAR-T 细胞，已经彻底改变了当代癌症治疗。本文综述了免疫细胞调控和癌症免疫疗法的最新进展。由于各种免疫疗法的进步，如单克隆抗体、重组蛋白、疫苗（预防性和治疗性）、细胞免疫疗法和细胞因子，有多种选择可用于治疗许多疾病，特别是癌症。
展开英文摘要原文
Cancer immunotherapy moderates the immune system's ability to fight cancer. Due to its extreme complexity, scientists are working to put together all the puzzle pieces to get a clearer picture of the immune system. Shreds of available evidence show the connection between cancer and the immune system. Immune responses to tumors and lymphoid malignancies are influenced by B cells, γδT cells, NK cells, and dendritic cells (DCs).
Cancer immunotherapy, which encompasses adoptive cancer therapy, monoclonal antibodies (mAbs), immune checkpoint therapy, and CART cells, has revolutionized contemporary cancer treatment. This article reviews recent developments in immune cell regulation and cancer immunotherapy. Various options are available to treat many diseases, particularly cancer, due to the progress in various immunotherapies, such as monoclonal antibodies, recombinant proteins, vaccinations (both preventative and curative), cellular immunotherapies, and cytokines.
论文信息
- 作者
- Mukherjee AG、Wanjari UR、Namachivayam A、Murali R、Prabakaran DS、Ganesan R、Renu K、Dey A
- 单位
- Department of Biomedical Sciences, School of Biosciences and Technology, Vellore Institute of Technology (VIT), Vellore 632014, Tamil Nadu, India.India
- 文献类型
- 综述
- 期刊
- Vaccines2022 Sep 7
- 原文标识
- PubMed 36146572 · DOI 10.3390/vaccines10091493
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