CD81 通过阻断 CD274/PD-L1 的选择性自噬降解驱动放射抵抗性胶质母细胞瘤的免疫逃逸
CD81 drives immune evasion in radioresistant glioblastoma by blocking selective autophagic degradation of CD274/PD-L1.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
细胞外囊泡：纳米医学与癌症治疗中的新型工具
英文原题：Extracellular Vesicles: A Novel Tool in Nanomedicine and Cancer Treatment.
查看英文原题
Extracellular Vesicles: A Novel Tool in Nanomedicine and Cancer Treatment.
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中文摘要
细胞外囊泡是由细胞释放、具有膜结构的囊泡，可介导细胞间通信并维持稳态。多种外界刺激及细胞内在异常都会改变细胞外囊泡的组成环境。细胞发生变化会影响细胞外囊泡生成及其携带的内容物，这些改变可能进一步影响与之接触的近端或远端细胞。因此，分析细胞外囊泡特征的变化，可用于追踪疾病进展、发现改善治疗的潜在靶点，也可将其作为治疗介质。此外，近期研究已开发出改变细胞外囊泡载荷的方法，以恢复正常功能或递送治疗药物。本文考察癌细胞来源细胞外囊泡与正常细胞来源囊泡的差异、这些改变如何促进癌症进展，以及如何利用细胞外囊泡作为治疗药物靶向癌细胞和癌症相关间质。本文将细胞外囊泡介绍为纳米医学领域的一种新工具。
展开英文摘要原文
Extracellular vesicles are membrane-bound vesicles released by cells to mediate intercellular communication and homeostasis. Various external stimuli as well as inherent abnormalities result in alterations in the extracellular vesicle milieu. Changes to cells result in alterations in the content of the extracellular vesicle biogenesis, which may affect proximal and distal cells encountering these altered extracellular vesicles.
Therefore, the examination of changes in the extracellular vesicle signature can be used to follow disease progression, reveal possible targets to improve therapy, as well as to serve as mediators of therapy.
Furthermore, recent studies have developed methods to alter the cargo of extracellular vesicles to restore normal function or deliver therapeutic agents. This review will examine how extracellular vesicles from cancer cells differ from normal cells, how these altered extracellular vesicles can contribute to cancer progression, and how extracellular vesicles can be used as a therapeutic agent to target cancer cells and cancer-associated stroma.
Here we present extracellular vesicles as a novel tool in nanomedicine.
论文信息
- 作者
- Stavrou A、Ortiz A
- 单位
- Department of Medicine, Division of Environmental Medicine, New York University Grossman School of Medicine, New York, NY 10010, USA.United States
- 文献类型
- 综述
- 期刊
- Cancers2022 Sep 14
- 原文标识
- PubMed 36139610 · DOI 10.3390/cancers14184450
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