← 返回

是否必须将所有未达完全缓解的复发弥漫大 B 细胞淋巴瘤患者排除在自体干细胞移植之外?

英文原题:Do we have to exclude all relapsed diffuse large B-cell lymphoma patients not in complete remission from autologous stem cell transplant?

查看英文原题

Do we have to exclude all relapsed diffuse large B-cell lymphoma patients not in complete remission from autologous stem cell transplant?

PubMed 2022/09/19(内容时间) Br J Haematol Q2 · IF 3.6(JCR 2025)

分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。

中文摘要

随着嵌合抗原受体 CAR-T 细胞疗法问世,复发/难治性弥漫性大 B 细胞淋巴瘤的治疗仍面临挑战。是否应调整移植资格标准,以及是否应以其取代标准自体移植治疗,目前仍有争议。Cherng 及其同事利用 PET 参数得出的报告提示,即使患者仍有 PET 阳性残余肿块,接受标准治疗后仍可达到 54% 的五年生存率。

展开英文摘要原文

Treatment of relapsed/refractory diffuse large B-cell lymphoma remains a challenge with the advent of chimaeric antigen receptor CAR-T cell treatment. Whether or not eligibility criteria should replace the standard autologous transplantation is debated. By using PET-derived parameters, the report of Cherng and colleagues suggests that patients with positive residual mass can have a five-year survival of 54% with standard treatment.

论文信息

作者
Gisselbrecht C、Sibon D
第一作者单位
Hopital Saint Louis, Paris Cité University, Paris, France.France
通讯作者单位
Lymphoid Malignancies Department, Henri Mondor University Hospital, AP-HP, Créteil, France.France
文献类型
评论
期刊
British journal of haematology2023 Jan
原文标识
PubMed 36120952 · DOI 10.1111/bjh.18468