间皮素作为癌症免疫治疗的生物标志物和治疗靶点
Mesothelin as Biomarker and Therapeutic Target for Immunotherapy in Cancer.
癌症仍是一个关键的全球健康问题，原因在于发现晚、耐药和高死亡率。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
肿瘤浸润性 CD226(+)CD8(+) T 细胞与胃癌患者术后预后及辅助化疗获益相关
英文原题：Tumor-infiltrating CD226(+)CD8(+) T cells are associated with postoperative prognosis and adjuvant chemotherapeutic benefits in gastric cancer patients.
查看英文原题
Tumor-infiltrating CD226(+)CD8(+) T cells are associated with postoperative prognosis and adjuvant chemotherapeutic benefits in gastric cancer patients.
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研究概要
CD226 + CD8 + T 细胞可能代表 GC 患者的一种新型治疗靶点，以及预后和治疗反应的有用标志物。
研究思路结论见上方概要
目的
定义胃癌（GC）中CD8+ T细胞亚群的表型特征有助于重塑肿瘤的免疫微环境，从而改善患者预后。CD226近期已被证实在多种恶性肿瘤中调控CD8+ T细胞的活性。然而，CD226+ CD8+ T细胞在GC中的临床相关性仍不清楚。
方法
复旦大学附属肿瘤医院（FUSCC）队列（n = 316）、癌症基因组图谱（TCGA）队列（n = 407）、KUGH/KUCM队列（n = 202）和亚洲癌症研究组织（ACRG）队列（n = 300）被纳入预后和辅助化疗（ACT）反应分析。采用流式细胞术和多重免疫染色对CD226 + CD8 + T细胞进行表征。
结果
CD226 + CD8 + T细胞预测接受根治性切除术的GC患者预后良好。CD226 + CD8 + T细胞浸润高的GC患者从辅助化疗中获益更多。CD155在GC组织中上调，并与瘤内CD226 + CD8 + T细胞浸润减少相关。瘤内CD226 + CD8 + T细胞与CD155的联合是GC患者的强预后预测指标。
展开英文摘要原文
PURPOSE
Defining the phenotypic characteristics of CD8 + T cell subsets in gastric cancer (GC) can help remodel the immune microenvironment of the tumor, thereby improving patient prognosis. CD226 has recently been shown to regulate the activity of CD8 + T cell in several malignancies. However, the clinical relevance of CD226 + CD8 + T cells in GC remains unclear.
METHODS
Fudan University Shanghai Cancer Center (FUSCC) cohort (n = 316), The Cancer Genome Atlas (TCGA) cohort (n = 407), KUGH/KUCM cohort (n = 202), and Asian Cancer Research Group (ACRG) cohort (n = 300) were included in prognosis and response to adjuvant chemotherapy (ACT) analyses. Flow cytometry and multiplex immunostaining were used to characterize CD226 + CD8 + T cells.
RESULTS
CD226 + CD8 + T cells predicted favorable outcomes in patients undergoing curative resection for GC. GC patients with high CD226 + CD8 + T cell infiltration benefitted more from adjuvant chemotherapy. CD155 is upregulated in GC tissues and is associated with decreased intra-tumoral CD226 + CD8 + T cell infiltration. The combination of intra-tumoral CD226 + CD8 + T cells and CD155 is a strong prognostic predictor in patients with GC.
CONCLUSION
CD226 + CD8 + T cells may represent a novel therapeutic target and a useful marker of prognosis and therapeutic response in patients with GC.
论文信息
- 作者
- Zhang Y、Zhao ZX、Gao JP、Huang YK、Huang H
- 第一作者单位
- Department of Gastric Surgery, Fudan University Shanghai Cancer Center, 270 Dongan Road, Shanghai, 200032, People's Republic of China.China
- 通讯作者单位
- Department of Gastric Surgery, Fudan University Shanghai Cancer Center, 270 Dongan Road, Shanghai, 200032, People's Republic of China. huahuangvip@sina.com.China
- 期刊
- Journal of cancer research and clinical oncology2023 Jul
- 原文标识
- PubMed 36107244 · DOI 10.1007/s00432-022-04346-x
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