单细胞追踪揭示黑色素瘤 TIL 治疗过程中肿瘤反应性 T 细胞的可塑性
Single-cell tracking reveals tumor-reactive T cell plasticity during melanoma TIL therapy.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
调节性 T 细胞在抗癌免疫中的意义：从发病机制到治疗
英文原题：Implications of regulatory T cells in anti-cancer immunity: from pathogenesis to therapeutics.
查看英文原题
Implications of regulatory T cells in anti-cancer immunity: from pathogenesis to therapeutics.
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中文摘要
调节性T细胞（Tregs）在维持免疫耐受和抑制炎症中发挥重要作用。然而，Tregs是激发有效抗肿瘤免疫应答的主要障碍。因此，抑制Tregs的活性是成功实现癌症免疫治疗的一种新颖且高效的途径。此外，利用基于Treg的策略来增强不同类型疾病中的抗肿瘤免疫正日益受到关注。本综述总结了Tregs介导抑制抗肿瘤免疫的关键机制，以及抑制或改变此类Tregs以改善抗肿瘤免疫应答的策略。本综述着重介绍了重要临床研究，还描述了当前基于Treg的癌症治疗干预措施，并讨论了通过分子靶向抑制Tregs的方法，这可能成为一种有效的癌症免疫治疗手段，并作为有害化疗药物的替代方案。
展开英文摘要原文
Regulatory T cells (Tregs) play an essential role in maintaining immune tolerance and suppressing inflammation.
However, Tregs present major hurdle in eliciting potent anti-cancer immune responses.
Therefore, curbing the activity of Tregs represents a novel and efficient way towards successful immunotherapy of cancer.
Moreover, there is an emerging interest in harnessing Treg-based strategies for augmenting anti-cancer immunity in different types of the disease. This review summarises the crucial mechanisms of Tregs' mediated suppression of anti-cancer immunity and strategies to suppress or to alter such Tregs to improve the immune response against tumors.
Highlighting important clinical studies, the review also describes current Treg-based therapeutic interventions in cancer, and discusses Treg-suppression by molecular targeting, which may emerge as an effective cancer immunotherapy and as an alternative to detrimental chemotherapeutic agents.
论文信息
- 作者
- Dwivedi M、Tiwari S、Kemp EH、Begum R
- 第一作者单位
- C. G. Bhakta Institute of Biotechnology, Faculty of Science, Uka Tarsadia University, Tarsadi, Surat, Gujarat, 394350, India.India
- 通讯作者单位
- Department of Biochemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara, 390 002, Gujarat, India.India
- 文献类型
- 综述
- 期刊
- Heliyon2022 Aug
- 原文标识
- PubMed 36082331 · DOI 10.1016/j.heliyon.2022.e10450
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