CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题：Dendritic Cell Vaccines: A Promising Approach in the Fight against Ovarian Cancer.
Dendritic Cell Vaccines: A Promising Approach in the Fight against Ovarian Cancer.
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卵巢癌（OC）是发达国家中最致命的妇科恶性肿瘤，也是全球女性癌症确诊患者中第七大死因。目前，针对OC已有多种疗法在使用，包括减瘤手术、化疗以及靶向治疗。尽管当前的标准治疗提高了生存率，但绝大多数OC患者仍会复发。此外，免疫疗法仅带来了微乎其微的患者获益，这可能归因于肿瘤微环境内复杂的免疫抑制网络。在此背景下，树突状细胞（DC）疫苗可作为OC现有治疗方案的潜在补充。在本综述中，我们概述了OC当前的疗法，重点关注免疫疗法。接着，我们通过强调不同的DC亚群及其在OC中的功能，突出了使用DC疫苗在OC中的潜力。最后，我们概述了当前DC疫苗策略在OC中的进展与不足，同时提供了可能改善患者预后的未来展望。
Ovarian cancer (OC) is the deadliest gynecological malignancy in developed countries and is the seventh-highest cause of death in women diagnosed with cancer worldwide. Currently, several therapies are in use against OC, including debulking surgery, chemotherapy, as well as targeted therapies. Even though the current standard-of-care therapies improve survival, a vast majority of OC patients relapse.
Additionally, immunotherapies have only resulted in meager patient outcomes, potentially owing to the intricate immunosuppressive nexus within the tumor microenvironment. In this scenario, dendritic cell (DC) vaccination could serve as a potential addition to the therapeutic options available against OC. In this review, we provide an overview of current therapies in OC, focusing on immunotherapies. Next, we highlight the potential of using DC vaccines in OC by underscoring the different DC subsets and their functions in OC.
Finally, we provide an overview of the advances and pitfalls of current DC vaccine strategies in OC while providing future perspectives that could improve patient outcomes.
在 PubMed 查看 → 出版商原文（DOI） 全文 PDF（PMC）· 可下载 治疗专题与资料阅读指南 资料来源与翻译说明 报告译文或资料问题 →
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