RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
NK 细胞及其外泌体在移植物抗宿主病与移植物抗白血病中的作用
英文原题：The Role of NK Cells and Their Exosomes in Graft Versus Host Disease and Graft Versus Leukemia.
查看英文原题
The Role of NK Cells and Their Exosomes in Graft Versus Host Disease and Graft Versus Leukemia.
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中文摘要
自然杀伤（NK）细胞是先天免疫细胞之一，在预防和控制肿瘤及病毒性疾病中发挥重要作用，但其在造血干细胞移植（HCT）中的作用尚未完全明确。然而，根据一些研究，这些细胞可以在不引起移植物抗宿主病（GVHD）的情况下预防感染和肿瘤复发。除NK细胞外，多项研究关注NK细胞来源外泌体的抗白血病效应，这些研究可突出其在移植物抗白血病（GVL）中的作用。本文旨在探讨关于NK细胞在异基因造血细胞移植中作用以及其外泌体在GVL中作用的各种文章的成果。此外，我们还讨论了这些细胞在HCT后巨细胞病毒感染中的抗病毒效应。
展开英文摘要原文
Natural killer (NK) cells are one of the innate immune cells that play an important role in preventing and controlling tumors and viral diseases, but their role in hematopoietic stem cell transplantation (HCT) is not yet fully understood.
However, according to some research, these cells can prevent infections and tumor relapse without causing graft versus host disease (GVHD).
In addition to NK cells, several studies are about the anti-leukemia effects of NK cell-derived exosomes that can highlight their roles in graft-versus-leukemia (GVL). In this paper, we intend to investigate the results of various articles on the role of NK cells in allogeneic hematopoietic cell transplantation and also their exosomes in GVL. Also, we have discussed the antiviral effects of these cells in post-HCT cytomegalovirus infection.
论文信息
- 作者
- Zafarani A、Taghavi-Farahabadi M、Razizadeh MH、Amirzargar MR、Mansouri M、Mahmoudi M
- 第一作者单位
- Department of Hematology and Blood Banking, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran.Iran
- 通讯作者单位
- Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Msc.M.Mhd@sbmu.ac.ir.Iran
- 文献类型
- 综述
- 期刊
- Stem cell reviews and reports2023 Jan
- 原文标识
- PubMed 35994137 · DOI 10.1007/s12015-022-10449-2