CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题：A Synopsis Clonal Hematopoiesis of Indeterminate Potential in Hematology.
A Synopsis Clonal Hematopoiesis of Indeterminate Potential in Hematology.
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意义未明的克隆性造血可定义为与血液系统肿瘤如骨髓增生异常综合征相关的基因突变。细胞减少症患者越来越多地接受外周血或骨髓的分子遗传学检测以用于诊断目的。最近，一个新的疾病实体被界定出来，以降低血液系统恶性肿瘤误诊的风险。这个新实体是髓系疾病的潜在前驱病变，类似于意义未明的单克隆丙种球蛋白病作为多发性骨髓瘤的潜在前驱病变。
Clonal hematopoiesis of indeterminate potential can be defined as genetic mutations that correlate in hematologic neoplasia such as myelodysplastic syndrome. Patients with cytopenia increasingly undergo molecular genetic tests of peripheral blood or bone marrow for diagnostic purposes.
Recently, a new entity has been demarcated to lessen the risk of incorrect diagnoses of hematologic malignancies. This new entity is a potential precursor of myeloid diseases, analogous to monoclonal gammopathy of undetermined significance as a potential precursor of multiple myeloma.
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