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胃肠道肿瘤细胞治疗的现状

英文原题:Current State of Cell Therapies for Gastrointestinal Cancers.

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Current State of Cell Therapies for Gastrointestinal Cancers.

PubMed 2022/07/01(内容时间) Cancer J Q3 · IF 2.1(JCR 2025)

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中文摘要

过继性细胞疗法包括多种基于细胞的疗法,旨在利用免疫系统的力量产生强大的抗癌效果。检查点抑制在实体瘤中的早期成功增加了免疫疗法的研究与开发。由于抗原特异性和进入肿瘤微环境的挑战,基于细胞的疗法在胃肠道恶性肿瘤中的应用仍处于起步阶段。在这篇综述中,我们讨论了过继性细胞疗法在临床前和临床研究中的挑战和早期成功方面的现状。

展开英文摘要原文

Adoptive cell therapies include multiple cell-based therapies to harness the immune system's power to mount a robust anticancer effect. Early successes in solid tumors with checkpoint inhibition have increased the research and development of immunotherapy.

The utilization of cell-based therapy for gastrointestinal malignancies is still in its infancy because of challenges of antigen specificity and access to the tumor microenvironment. In this review, we discuss the current state of adoptive cell therapies in terms of challenges and early successes in preclinical and clinical studies.

论文信息

作者
Kooragayala K、Lou J、Hong YK
第一作者单位
From the Department of Surgery, Cooper University Hospital, Camden, NJ.United States
文献类型
综述 · 美国 NIH 资助研究
期刊
Cancer journal (Sudbury, Mass.)2022 Jul-Aug 01
原文标识
PubMed 35880941 · DOI 10.1097/PPO.0000000000000611