工程化益生菌用于肿瘤靶向联合化学免疫治疗
Engineered probiotics for tumor-targeted combination chemoimmunotherapy.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
线粒体分裂通过降低 MHC-I 表面表达诱导实体瘤免疫逃逸
英文原题：Mitochondrial fission induces immunoescape in solid tumors through decreasing MHC-I surface expression.
查看英文原题
Mitochondrial fission induces immunoescape in solid tumors through decreasing MHC-I surface expression.
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中文摘要
线粒体动力学可调控小鼠和恶性肿瘤患者中癌细胞主要组织相容性复合体（MHC）-I抗原表达及其免疫原性。IRE1α-XBP-1s轴在线粒体碎片化与免疫原性的联系中发挥关键作用。XBP-1s是氨肽酶TPP2的转录因子，TPP2可能通过降解肿瘤抗原肽来抑制MHC-I复合物在细胞表面的表达。用Mdivi-1抑制线粒体分裂可上调癌细胞上的MHC-I表达，并增强患者来源肿瘤模型中过继性T细胞疗法的疗效。因此，抑制线粒体分裂可能提供一种增强基于T细胞的免疫疗法疗效的方法。
展开英文摘要原文
Mitochondrial dynamics can regulate Major Histocompatibility Complex (MHC)-I antigen expression by cancer cells and their immunogenicity in mice and in patients with malignancies. A crucial role in the mitochondrial fragmentation connection with immunogenicity is played by the IRE1α-XBP-1s axis.
XBP-1s is a transcription factor for aminopeptidase TPP2, which inhibits MHC-I complex cell surface expression likely by degrading tumor antigen peptides. Mitochondrial fission inhibition with Mdivi-1 upregulates MHC-I expression on cancer cells and enhances the efficacy of adoptive T cell therapy in patient-derived tumor models.
Therefore mitochondrial fission inhibition might provide an approach to enhance the efficacy of T cell-based immunotherapy.
论文信息
- 作者
- Lei X、Lin H、Wang J、Ou Z、Ruan Y、Sadagopan A、Chen W、Xie S
- 第一作者单位
- Department of Oral and Maxillofacial Surgery, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou, 510120, China.China
- 通讯作者单位
- Department of Oral and Maxillofacial Surgery, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou, 510120, China. lijins@mail.sysu.edu.cn.China
- 文献类型
- 美国 NIH 资助研究 · 非美国政府资助研究 · 美国政府（非公共卫生署）资助研究
- 期刊
- Nature communications2022 Jul 6
- 原文标识
- PubMed 35794100 · DOI 10.1038/s41467-022-31417-x
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