CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题：CRISPR: A Promising Tool for Cancer Therapy.
CRISPR: A Promising Tool for Cancer Therapy.
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称为CRISPR的成簇规律间隔短回文重复序列系统，是一项重要技术进展，使遗传学家和研究者能够进行基因组编辑。这项突破性技术迅速超越锌指核酸酶（ZFN）及其他编辑工具；其易用性和准确性已从基础科学研究到医学研究和治疗选择，全面改变了基因组编辑领域。该系统由两个关键部分组成：CRISPR相关（Cas）核酸酶可结合并切割脱氧核糖核酸（DNA）；引导RNA（gRNA）序列则将Cas核酸酶引导至靶位点。在研究领域，CRISPR除用于基因编辑外，还被用于表观基因组修饰、全基因组筛选及癌症靶向治疗等。本综述介绍CRISPR/Cas系统的当前研究认识，特别关注该系统与癌症治疗作用之间关系的研究。
The clustered regularly interspaced short palindromic repeats system, called CRISPR, as one of the major technological advances, allows geneticists and researchers to perform genome editing. This remarkable technology is quickly eclipsing zinc-finger nucleases (ZFNs) and other editing tools, and its ease of use and accuracy have thus far revolutionized genome editing, from fundamental science projects to medical research and treatment options.
This system consists of two key components: a CRISPR-associated (Cas) nuclease, which binds and cuts deoxyribonucleic acid (DNA) and a guide ribonucleic acid (gRNA) sequence, directing the Cas nuclease to its target site.
In the research arena, CRISPR has been up to now exploited in various ways alongside gene editing, such as epigenome modifications, genome-wide screening, targeted cancer therapies, and so on. This article reviews the current perceptions of the CRISPR/Cas systems with special attention to studies reflecting on the relationship between the CRISPR/Cas systems and their role in cancer therapy.
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