多发性骨髓瘤自体干细胞移植的并发症：CALM 研究结果

Background: The main goal of this post hoc analysis of the Collaboration to Collect Autologous Transplant Outcomes in Lymphoma and Myeloma (CALM) study was to evaluate the rate of short- and long-term infectious and non-infectious complications occurring after ASCT in patients with multiple myeloma (MM). Methods: The analysis included all patients with MM from the CALM study who underwent 1 ASCT. The primary endpoint of the analysis was to determine the rate of infectious and non-infectious complications after ASCT and to compare them in three time periods: 0 100 days, 101 days 1 year, and >1 year after the first transplant. Results: The analysis included a total of 3552 patients followed up for a median of 56. 7 months (range 0. 4 108. 1). Complication rates decreased with the time from ASCT with 24.

85 cases per 100 patient-years from day 0 to 100 days after the transplant, and <2. 31 cases per 100 patient-years from the 101st day. At 100 days after ASC T, 45. 7% of patients had complications, with infectious events being twice as frequent as non-infectious complications. Bacterial infections (6. 5 cases per 100 patient-years, 95% CI: 6. 1 7. 0) and gastrointestinal complications (4.

7 cases per 100 patient-years, 95% CI: 4. 3 5. 1) were the most common early events. The pattern of complications changed with time from ASCT. The presence of complications after ASCT was not associated with overall survival. Conclusions: Our data provide a solid basis for comparing ASCT-related complications to those caused by emerging treatments in multiple myeloma, such as CAR T-cell therapy and other immunotherapies.