γδ T 细胞调节小细胞肺癌中的抗肿瘤免疫
γδ T cells modulate anti-tumor immunity in small cell lung cancer.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
人 γδ T 细胞亚群及其在肿瘤免疫治疗中的临床应用
英文原题：Human γδ T Cell Subsets and Their Clinical Applications for Cancer Immunotherapy.
查看英文原题
Human γδ T Cell Subsets and Their Clinical Applications for Cancer Immunotherapy.
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中文摘要
γδ T细胞是数量较少的一类T细胞，同时具有适应性和先天免疫特征。与受主要组织相容性复合体（MHC）限制的αβ T细胞不同，γδ T细胞以MHC非依赖方式活化，因此是开发异体现货型细胞免疫疗法的理想候选。随着癌症免疫治疗领域迅速发展，研究者已探索γδ T细胞的不同亚群。此外，可采用不同基因编辑技术改造γδ T细胞，增强其肿瘤识别能力和抗肿瘤功能。本综述概述人γδ T细胞不同亚群的独特特征和抗肿瘤作用，并总结既往及正在进行的γδ T细胞癌症免疫疗法临床前研究和临床试验。
展开英文摘要原文
Gamma delta ( ) T cells are a minor population of T cells that share adaptive and innate immune properties. In contrast to MHC-restricted alpha beta ( ) T cells, T cells are activated in an MHC-independent manner, making them ideal candidates for developing allogeneic, off-the-shelf cell-based immunotherapies. As the field of cancer immunotherapy progresses rapidly, different subsets of T cells have been explored.
In addition, T cells can be engineered using different gene editing technologies that augment their tumor recognition abilities and antitumor functions. In this review, we outline the unique features of different subsets of human T cells and their antitumor properties.
We also summarize the past and the ongoing pre-clinical studies and clinical trials utilizing T cell-based cancer immunotherapy.
论文信息
- 作者
- Lee D、Rosenthal CJ、Penn NE、Dunn ZS、Zhou Y、Yang L
- 单位
- Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, CA 90095, USA.United States
- 文献类型
- 综述
- 期刊
- Cancers2022 Jun 18
- 原文标识
- PubMed 35740670 · DOI 10.3390/cancers14123005
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