CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
人类 FOXP3 与肿瘤微环境
英文原题：Human FOXP3 and tumour microenvironment.
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Human FOXP3 and tumour microenvironment.
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中文摘要
肿瘤微环境（TME）是由癌细胞、基质细胞和免疫细胞组成的复杂系统。TME中的调节性T细胞（Tregs）阻碍肿瘤的免疫监视并抑制抗肿瘤免疫应答。转录因子叉头框蛋白3（FOXP3）是Tregs的主要标志物，主导Tregs的功能。FOXP3最初被认为是Tregs特异性表达分子，近年研究发现FOXP3在多种肿瘤中表达，且功能作用不一致。本文综述了TME中浸润性Treg-FOXP3和肿瘤-FOXP3的最新进展，探讨了TME中FOXP3+细胞与效应T细胞之间的通讯机制、FOXP3与临床预后的关系以及FOXP3靶向治疗的潜力。
展开英文摘要原文
The tumour microenvironment (TME) is a complex system composed of cancer cells, stromal cells and immune cells. Regulatory T cells (Tregs) in the TME impede immune surveillance of tumours and suppress antitumor immune responses. Transcription factor forkhead box protein 3 (FOXP3) is the main marker of Tregs, which dominates the function of Tregs.
FOXP3 was originally thought to be a Tregs-specific expression molecule, and recent studies have found that FOXP3 is expressed in a variety of tumours with inconsistent functional roles. This review summarizes the recent progress of infiltrating Treg-FOXP3 and tumour-FOXP3 in TME, discusses the communication mechanism between FOXP3 + cells and effector T cells in TME, the relationship between FOXP3 and clinical prognosis, and the potential of FOXP3-targeted therapy.
论文信息
- 作者
- Wang J、Gong R、Zhao C、Lei K、Sun X、Ren H
- 单位
- Center of Tumor Immunology and Cytotherapy, Medical Research Center, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.China
- 文献类型
- 综述 · 非美国政府资助研究
- 期刊
- Immunology2023 Feb
- 原文标识
- PubMed 35689826 · DOI 10.1111/imm.13520