CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
胶质母细胞瘤微环境中淋巴细胞与小胶质细胞的对话
英文原题：Dialogue among Lymphocytes and Microglia in Glioblastoma Microenvironment.
查看英文原题
Dialogue among Lymphocytes and Microglia in Glioblastoma Microenvironment.
分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。
中文摘要
小胶质细胞和淋巴细胞是胶质母细胞瘤微环境的基本组成部分。本文综述目前关于小胶质细胞促进这种致命脑肿瘤发生和侵袭性特征的最新认识。我们特别回顾胶质母细胞瘤模型及患者体外和体内研究，阐明肿瘤进展过程中小胶质细胞、淋巴细胞和肿瘤细胞之间形成的双向共生互作。此外，我们重点介绍旨在重塑这些相互作用的当前实验性治疗方法，例如腺相关病毒（AAV）递送、CAR-T 和 CAR-NK 细胞输注，以及以抗肿瘤方式调节肿瘤微环境，从而抑制胶质母细胞瘤生长。
展开英文摘要原文
Microglia and lymphocytes are fundamental constituents of the glioblastoma microenvironment. In this review, we summarize the current state-of-the-art knowledge of the microglial role played in promoting the development and aggressive hallmarks of this deadly brain tumor. Particularly, we report in vitro and in vivo studies related to glioblastoma models and human patients to outline the symbiotic bidirectional interaction between microglia, lymphocytes, and tumor cells that develops during tumor progression.
Furthermore, we highlight the current experimental therapeutic approaches that aim to shape these interplays, such as adeno-associated virus (AAV) delivery and CAR-T and -NK cell infusion, and to modulate the tumor microenvironment in an anti-tumoral way, thus counteracting glioblastoma growth.
论文信息
- 作者
- Mormino A、Garofalo S
- 单位
- Department of Physiology and Pharmacology, Sapienza University, 00185 Rome, Italy.Italy
- 文献类型
- 综述
- 期刊
- Cancers2022 May 26
- 原文标识
- PubMed 35681612 · DOI 10.3390/cancers14112632
在 PubMed 查看 → 出版商原文（DOI） 全文 PDF（PMC）· 可下载 治疗专题与资料阅读指南 资料来源与翻译说明 报告译文或资料问题 →