CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
自我反应性、先天样 T 细胞增强细胞毒性和免疫监视
英文原题：Self-reactive, innate-like T cells enhance cytotoxicity and immunosurveillance.
查看英文原题
Self-reactive, innate-like T cells enhance cytotoxicity and immunosurveillance.
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中文摘要
检查点阻断和过继性T细胞疗法对部分患者有效，但许多患者对这些免疫疗法无应答。Chou等人最近阐明了一种新型细胞群体的特征，与传统细胞毒性T细胞相比，该细胞群体具有更强的细胞毒性、更好的肿瘤归巢能力以及更少的耗竭。这些细胞可能提高癌症免疫疗法的疗效，尤其是对于当前方法难治或无应答的患者。
展开英文摘要原文
Checkpoint blockade and adoptive T cell therapy are efficacious in some patients, but many do not respond to these immunotherapies. Chou et al. recently elucidated the characteristics of a new cell population with greater cytotoxicity, improved tumor homing, and reduced exhaustion compared to conventional cytotoxic T cells. These cells may improve the efficacy of cancer immunotherapies, especially for patients refractory or unresponsive to current approaches.
论文信息
- 作者
- Barton BE、Chau CH、Figg WD
- 第一作者单位
- Molecular Pharmacology Section, Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.United States
- 通讯作者单位
- Molecular Pharmacology Section, Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address: figgw@mail.nih.gov.United States
- 文献类型
- 美国 NIH 院内研究 · 评论
- 期刊
- Trends in cancer2022 Aug
- 原文标识
- PubMed 35672242 · DOI 10.1016/j.trecan.2022.05.003
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